About this Research Topic
In all organisms, the DNA replication machinery is responsible for accurate and efficient duplication of the chromosome. Inhibitors of replication proteins are commonly used in anti-cancer and anti-viral therapies. This Research Topic will examine the normal functions of replication proteins and strategies to target each step during the replication process including helicases, replication and lesion bypass DNA polymerases, topoisomerases and DNA repair enzymes. Articles will discuss current strategies to develop drugs targeting DNA replication proteins as well as future outlooks and needs.
Keywords: DNA replication, DNA polymerase, DNA helicase, topoisomerase, anti-cancer therapies, anti-viral therapies, translesion DNA polymerase, nucleoside inhibitors, mitochondrial DNA polymerase
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