Neurodegenerative Disorders: Common Mechanisms, Early Markers, Innovative Therapeutics

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Umberto di Porzio

National Research Council (CNR)

Noel Buckley

King's College London

Gian Carlo Bellenchi

Institute of Genetics and Biophysics Adriano Buzzati-Traverso, Department of Biomedical Sciences, National Research Council (CNR)

Massimiliano Caiazzo

Utrecht University

Giuseppe Di Fede

IRCCS Carlo Besta Neurological Institute Foundation

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Recent advances highlight the existence of common mechanisms underlying many neurodegenerative diseases, including Alzheimer’s, Parkinson’s, Huntington’s and ALS, all of which show overlapping molecular, cellular and behavioral phenotypes. It is now accepted that neurodegeneration and neuronal death are the final manifestation of pathophysiological changes that arise many years before behavioral symptoms. Hence, unraveling the early molecular mechanisms is of pivotal importance to understanding the pathogenesis of these diseases, identifying novel therapeutic targets, and developing treatments to delay, slow or block disease progression.

Recent advances in stem cell biology, genomics, gene-editing, systems pharmacology, and bioinformatics are all contributing to a broad, multi-modal understanding of disease mechanism, and are providing a new generation of tools to enable therapeutic intervention. Exploring the shared commonality of disease mechanisms opens up opportunities to identify targets that may of therapeutic benefit to more than one disease.

This Research Topic thus aims to explore the commonality across neurodegenerative disorders, increase our understanding of their pathogenesis, and articulate strategies to use this knowledge to deliver novel therapeutic tools.

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Editors

Umberto di Porzio

National Research Council (CNR)

Noel Buckley

King's College London

Gian Carlo Bellenchi

Institute of Genetics and Biophysics Adriano Buzzati-Traverso, Department of Biomedical Sciences, National Research Council (CNR)

Massimiliano Caiazzo

Utrecht University

Giuseppe Di Fede

IRCCS Carlo Besta Neurological Institute Foundation

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82,634 Total views

61,983 Article views

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Published In

Frontiers in Neuroscience

Neurodegeneration

Frontiers in Molecular Neuroscience

Pain Mechanisms and Modulators

Frontiers in Psychiatry

Neurodegeneration

Frontiers in Neurology

Neurodegeneration

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