About this Research Topic
Fine-tune regulation of neuronal cytoskeleton is therefore crucial for the maintenance of neuronal integrity and functionality. Mutations in genes that code for cytoskeletal proteins often have deleterious effects in neurons, such as abnormal migration or differentiation, deficient axonal transport of organelles and synaptic vesicles, or impaired synaptic signaling. Several human Nervous System disorders, including neurodevelopmental, psychiatric, and neurodegenerative diseases, have been linked to cytoskeletal dysfunction. Cytoskeletal reorganization is also crucial to regulate nerve cell repair following Nervous System injury. Many of the pathways that control cell-intrinsic axon regeneration lead to axon cytoskeletal remodeling. Moreover, most extracellular cues that inhibit regeneration of damaged axons in Central Nervous System following traumatic injury or neurodegeneration, are known to modulate cytoskeletal dynamics and organization. Based on these findings, regulators of cytoskeleton dynamics have emerged as promising therapeutic targets in several brain disorders and in the context of regeneration of injured axons.
Hence, remodeling of neuronal cytoskeleton underlies all the dramatic morphological changes that occur in developing and adult neurons. Understanding the specific molecular mechanisms that control cytoskeleton rearrangements in neurons is far from complete. This Frontiers Research Topic aims to gather a selection of articles focused on the diverse and key roles of cytoskeleton in neuronal biology.
Articles on the following themes are welcome:
I. Roles of the cytoskeleton in neuronal polarity
II. The growth cone cytoskeleton
III. Cytoskeletal dynamics in dendrite and axon outgrowth and guidance
IV. Cytoskeleton function and dysfunction during neuronal migration
V. Cytoskeleton in synaptogenesis and synaptic plasticity
VI. Nervous System disorders associated to cytoskeleton dysfunction: from neurodevelopmental to psychiatric and neurodegenerative disorders.
VII. Cytoskeleton remodeling during axon regeneration
Different types of articles are welcome in this Topic, i.e. original contributions, reviews and novel methods.
Keywords: neuronal cytoskeleton, microtubules, actin filaments, neurofilaments, neuronal development, brain disorders, neurodegeneration, axonal regeneration
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.