About this Research Topic
Cancer is a multifactorial disease accounted to be the second leading cause of morbidity and death worldwide. The impact of cancer is often estimated in terms of clinical endpoints such as the risk of recurrence and the probability of remission and survival. Genome integrity promoted by different DNA repair pathways is one of the key factors to suppress tumor initiation and modulates the immunogenicity of the tumor. The recent technology development in genetics and genomic approaches increases the opportunity to uncover the mechanisms of the disease and open the possibilities of new therapies. In this regard, the DNA repair targeted therapy, targeting metabolism, chemotherapy, and immunotherapy as a single or in combinatorial treatment approaches have made significance progress in several types of cancer. However, the treatment outcomes are limited due to low response rate that are associated with resistance to those treatment modalities due to low immunogenicity of the tumor microenvironment.
This Editor’s Challenge Research Topics invites manuscripts exploring the DNA repair defect, metabolic demand of the cancer cells implication for tumor immunogenicity, and immune based therapy.
Potential’s themes of include:
-Examine the crossroad of cancer cells innate immune signaling.
-Novel DNA repair targeted treatment approaches to enhance immunotherapy.
-How DNA repair aberration in cancer cells influence cancer cell-intrinsic immune signaling
and immune phenotypes.
-Is the cancer cells intrinsic innate immune signaling factors is critical for innate immune cell
inflammatory signaling activation?
-Decoding cancer cells metabolism to enhance DNA damage associated genetic vulnerability
to enhance the efficacy of targeted therapy and immunotherapy.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
This Editor’s Challenge Research Topics invites manuscripts exploring the DNA repair defect, metabolic demand of the cancer cells implication for tumor immunogenicity, and immune based therapy.
Potential’s themes of include:
-Examine the crossroad of cancer cells innate immune signaling.
-Novel DNA repair targeted treatment approaches to enhance immunotherapy.
-How DNA repair aberration in cancer cells influence cancer cell-intrinsic immune signaling
and immune phenotypes.
-Is the cancer cells intrinsic innate immune signaling factors is critical for innate immune cell
inflammatory signaling activation?
-Decoding cancer cells metabolism to enhance DNA damage associated genetic vulnerability
to enhance the efficacy of targeted therapy and immunotherapy.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: metabolism, immunotherapy, cancer, oncology, DNA damage
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
