The global increase in life expectancy and decline in fertility rates have led to a rapidly aging population. It is projected that the proportion of individuals over 65 years old will double by 2050, accompanied by a corresponding rise in the number of dementia cases. To prevent the enormous social and economic impact associated with dementia, new strategies to prevent, treat, or cure it are needed. Pathophysiological alterations in the brain begin more than 20 years before the first clinical manifestations of dementia. In the last decades the molecular mechanism underlying aging, have been studied leading to the identification of 14 age-related molecular and cellular alteration that have been classified as hallmarks of aging. Most of these hallmarks have also been observed in aging neurons and have been associated with dementia. Considering that cognitive decline without substantial neuronal loss is part of the physiological aging process and that aging itself is a major risk factor for dementia, we believed that studies focusing on cellular and molecular mechanisms associated with the early divergence of healthy and pathological aging can provide relevant data on the divergence of hallmarks of aging during the transition from a physiological to a pathological state. These alterations could reveal new therapeutic approaches to treat, cure, or prevent dementia.
This Research Topic aims to elucidate the divergence in cellular and molecular pathways associated with the Transition Between Healthy Aging and Dementia. We welcome the submission of original research, case studies, reviews, meta-analyses, and methodological studies. The subtopic of interest includes:
• Biochemical and/ or genetic alterations associated with the transition between healthy aging and Dementia
• Epigenetic mechanisms in the transition between healthy aging and dementia
• The Relationship between Genomic instability and the transition from health aging to dementia
• Relationship between the loss of proteostasis and early onset of dementia
• Changes in mitochondria function during in early stages of dementia
• Relationship between Mechanisms associated with deregulated nutrient sensing the transition between healthy aging to dementia
The global increase in life expectancy and decline in fertility rates have led to a rapidly aging population. It is projected that the proportion of individuals over 65 years old will double by 2050, accompanied by a corresponding rise in the number of dementia cases. To prevent the enormous social and economic impact associated with dementia, new strategies to prevent, treat, or cure it are needed. Pathophysiological alterations in the brain begin more than 20 years before the first clinical manifestations of dementia. In the last decades the molecular mechanism underlying aging, have been studied leading to the identification of 14 age-related molecular and cellular alteration that have been classified as hallmarks of aging. Most of these hallmarks have also been observed in aging neurons and have been associated with dementia. Considering that cognitive decline without substantial neuronal loss is part of the physiological aging process and that aging itself is a major risk factor for dementia, we believed that studies focusing on cellular and molecular mechanisms associated with the early divergence of healthy and pathological aging can provide relevant data on the divergence of hallmarks of aging during the transition from a physiological to a pathological state. These alterations could reveal new therapeutic approaches to treat, cure, or prevent dementia.
This Research Topic aims to elucidate the divergence in cellular and molecular pathways associated with the Transition Between Healthy Aging and Dementia. We welcome the submission of original research, case studies, reviews, meta-analyses, and methodological studies. The subtopic of interest includes:
• Biochemical and/ or genetic alterations associated with the transition between healthy aging and Dementia
• Epigenetic mechanisms in the transition between healthy aging and dementia
• The Relationship between Genomic instability and the transition from health aging to dementia
• Relationship between the loss of proteostasis and early onset of dementia
• Changes in mitochondria function during in early stages of dementia
• Relationship between Mechanisms associated with deregulated nutrient sensing the transition between healthy aging to dementia
