About this Research Topic
In addition, several new diagnostic approaches for IA diagnosis have been studied within the last years (for example the Aspergillus specific lateral flow assay, imaging studies using radiolabeled siderophores, analyses of volatile organic compounds in exhaled breath samples, new proxim-ity ligation assays and so on). These new diagnostic approaches may overcome the limitations observed with the currently available diagnostic tools, like e.g., decreased sensitivities under antifungal prophylax-es/treatment, low specificity, long turn-around times.
In contrast to the invasive form chronic pulmonary Aspergillosis (CPA) is usually seen in immunocompetent patients with underlying respiratory diseases.
The vast majority with 1.2 out of 3 mil-lion CPA patients worldwide develop CPA as sequel to pulmonary tuberculosis. Hence, the highest burden of CPA might be covered by high TB incidence countries of low-resources. Disease severity and progression is highly variable with a five year fatality rate between 40-60%. Diagnosis is often challenging and made by a combination of characteristics. To prove mycological evidence Aspergillus IgG antibody assays are high-ly recommend with variable sensitivity and specificity depending on which assay is used. Management of CPA patients needs a long-term commitment with a multimodal and personalized approach.
This Research Topic will welcome the following manuscript types focusing on diagnosis of invasive and chronic forms of Aspergillosis: Original Research, Case Reports, Reviews, Mini-Reviews, Clinical Trial Protocols. We particularly welcome articles reporting novel diagnostic approaches, or involving novel patient groups for more established diagnostic tests.
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