Lipid mediators are crucial signaling molecules generated through intricate biosynthetic pathways. They serve pivotal roles in a range of physiological processes, encompassing inflammation, blood pressure regulation, and energy metabolism. Dysregulation of various lipid mediators, including prostaglandins, leukotrienes, resolvins, sphingolipids, and endocannabinoids, contributes significantly to the pathophysiology of diverse diseases. Recent advancements are uncovering novel lipid mediators, their receptors, and cellular targets. This Research Topic aims to encompass the expanding landscape of lipid mediator functions within physiological systems and their underlying cellular signaling mechanisms.
This research topic aims to collect manuscripts on:
• Significance of lipid mediator receptors in regulating physiological responses
• Involvement of lipid mediators in disease processes
• Cellular and molecular mechanisms underlying bioactive lipid actions
• Pharmacological regulation of lipid mediators and receptor function
• Bioactive lipids as mediators of organ crosstalk and coordination
• Lipid mediators and their influence on gene regulation
Prof John Imig declares the following conflicts of interest: (1) Nephraegis, Founding Inventor and Scientific Consultant, (2) MetaSyn, Founding Inventor and Scientific Consultant, (3) Several Patents for small molecules that manipulate lipids - receiving royalties from the Medical College of Wisconsin and (4) Frontiers SA - Chief Editor, Frontiers in Physiology. All other Topic Editors declare no conflicts of interest. All other Topic Editors declare no conflicts of interest.
Lipid mediators are crucial signaling molecules generated through intricate biosynthetic pathways. They serve pivotal roles in a range of physiological processes, encompassing inflammation, blood pressure regulation, and energy metabolism. Dysregulation of various lipid mediators, including prostaglandins, leukotrienes, resolvins, sphingolipids, and endocannabinoids, contributes significantly to the pathophysiology of diverse diseases. Recent advancements are uncovering novel lipid mediators, their receptors, and cellular targets. This Research Topic aims to encompass the expanding landscape of lipid mediator functions within physiological systems and their underlying cellular signaling mechanisms.
This research topic aims to collect manuscripts on:
• Significance of lipid mediator receptors in regulating physiological responses
• Involvement of lipid mediators in disease processes
• Cellular and molecular mechanisms underlying bioactive lipid actions
• Pharmacological regulation of lipid mediators and receptor function
• Bioactive lipids as mediators of organ crosstalk and coordination
• Lipid mediators and their influence on gene regulation
Prof John Imig declares the following conflicts of interest: (1) Nephraegis, Founding Inventor and Scientific Consultant, (2) MetaSyn, Founding Inventor and Scientific Consultant, (3) Several Patents for small molecules that manipulate lipids - receiving royalties from the Medical College of Wisconsin and (4) Frontiers SA - Chief Editor, Frontiers in Physiology. All other Topic Editors declare no conflicts of interest. All other Topic Editors declare no conflicts of interest.