Plant growth, development, and responses to environmental stress are accompanied by fluctuations in the levels of reactive oxygen/nitrogen/sulfur species (ROS/RNS/RSS), which impact the cellular redox state. These reactive species actively participate in cellular signaling pathways by inducing redox post-translational modifications (PTMs) on protein cysteine thiols, also known as sulfhydryl groups (-SH), thereby modifying protein function. Protein thiols are highly reactive and undergo various PTMs through enzymatic or non-enzymatic reactions, which can be reversed by redoxins (such as thioredoxin and glutaredoxin) and metabolites (such as glutathione and ascorbate). Consequently, protein thiols act as "redox switches," leading to distinct functional effects in proteins. Thiol-based redox regulation, therefore, plays a crucial role in maintaining cellular homeostasis and coordinating various biological processes in plants.
In recent years, significant progress has been made in advancing our understanding of thiol-based redox regulation in plants through contemporary proteomics, structural analysis, advanced real-time imaging techniques using genetic or chemical probes, and redox functional analysis. Despite these advancements, several challenges remain to be addressed, particularly in the elucidation of how thiol-based redox switches specifically regulate different signaling pathways. Additionally, a comprehensive understanding of the crosstalk between different signaling pathways and the integration of redox signaling with other cellular processes will be crucial to fully elucidate the intricate regulatory networks governed by thiol-based redox switches.
This Research Topic aims to offer a comprehensive overview of recent breakthroughs in thiol-based redox regulation in plants. We eagerly invite high-quality contributions that align within this theme, including all article types that are accepted by the Plant Proteomics and Protein Structural Biology section. The scope of this Research Topic encompasses various areas which may include, but are not limited to:
• Advancements in proteomic techniques for studying thiol-based redox regulation.
• Development and utilization of research resources, such as websites, datasets, or toolboxes, to enhance our understanding of plant thiol-based redox regulation.
• Structural analysis of proteins involved in thiol-based redox signaling.
• Functional and biochemical investigations to uncover the roles of cysteine modifications and thiol-based redox switches in plant physiology.
• Exploration of thiol-regulated ROS, RNS, and RSS homeostasis in plants.
Keywords:
Thiol signaling, redox regulation, reactive molecular species, post-translational modifications
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Plant growth, development, and responses to environmental stress are accompanied by fluctuations in the levels of reactive oxygen/nitrogen/sulfur species (ROS/RNS/RSS), which impact the cellular redox state. These reactive species actively participate in cellular signaling pathways by inducing redox post-translational modifications (PTMs) on protein cysteine thiols, also known as sulfhydryl groups (-SH), thereby modifying protein function. Protein thiols are highly reactive and undergo various PTMs through enzymatic or non-enzymatic reactions, which can be reversed by redoxins (such as thioredoxin and glutaredoxin) and metabolites (such as glutathione and ascorbate). Consequently, protein thiols act as "redox switches," leading to distinct functional effects in proteins. Thiol-based redox regulation, therefore, plays a crucial role in maintaining cellular homeostasis and coordinating various biological processes in plants.
In recent years, significant progress has been made in advancing our understanding of thiol-based redox regulation in plants through contemporary proteomics, structural analysis, advanced real-time imaging techniques using genetic or chemical probes, and redox functional analysis. Despite these advancements, several challenges remain to be addressed, particularly in the elucidation of how thiol-based redox switches specifically regulate different signaling pathways. Additionally, a comprehensive understanding of the crosstalk between different signaling pathways and the integration of redox signaling with other cellular processes will be crucial to fully elucidate the intricate regulatory networks governed by thiol-based redox switches.
This Research Topic aims to offer a comprehensive overview of recent breakthroughs in thiol-based redox regulation in plants. We eagerly invite high-quality contributions that align within this theme, including all article types that are accepted by the Plant Proteomics and Protein Structural Biology section. The scope of this Research Topic encompasses various areas which may include, but are not limited to:
• Advancements in proteomic techniques for studying thiol-based redox regulation.
• Development and utilization of research resources, such as websites, datasets, or toolboxes, to enhance our understanding of plant thiol-based redox regulation.
• Structural analysis of proteins involved in thiol-based redox signaling.
• Functional and biochemical investigations to uncover the roles of cysteine modifications and thiol-based redox switches in plant physiology.
• Exploration of thiol-regulated ROS, RNS, and RSS homeostasis in plants.
Keywords:
Thiol signaling, redox regulation, reactive molecular species, post-translational modifications
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.