Understanding the interaction between the immune system and other organs is crucial in dealing with diseases, trauma, and degenerative scenarios. This requires focused attention not only to the immune system's parts (e.g., proteins, receptors, and cell types) but also to the tissues and organs involved in the clinical condition under consideration. Organs such as bone and the immune systems share a variety of molecules, such as cytokines, transcription factors, and relevant signalling molecules. At the cellular level, immune cells communicate by humoral factors to cells of the bone, the endocrine, gastrointestinal, and nervous systems. In fact, upon activation of the immune system, a variety of molecules including cytokines are released that directly affect other organs, their crosstalk to other organs and the immune system itself.
The goal of this Research Topic is to summarize recent advances in the field of organ crosstalk with the immune system and/or with other organs in the presence of an activated immune system.
We welcome the submission of Review articles (comprehensive, systematic, or mini format), Original Research articles describing basic, translational and/or clinical studies, Methods articles, and Perspective or Opinion articles.
The articles should be focused on, but not limited to, the following topics:
• Specific organ responses to an activated immune system in the context of trauma, musculoskeletal diseases, or regenerative scenarios
• Organ crosstalk in the context of trauma, musculoskeletal diseases, or regenerative scenarios
• Main players on organ crosstalk, e.g. cytokines, chemokines, proteins, receptors, cells, etc.
• Immunotherapeutic approaches to selectively target dysregulated immune responses in trauma, musculoskeletal diseases, or regenerative scenarios
• In vitro models, e.g. organ-on-chip, organoids, etc. to study organ crosstalk in a compromised immune scenario
• Animal models to study organ crosstalk in a compromised immune scenario
• Clinical relevance of organ crosstalk in the context of trauma, musculoskeletal diseases, or regenerative scenarios
Understanding the interaction between the immune system and other organs is crucial in dealing with diseases, trauma, and degenerative scenarios. This requires focused attention not only to the immune system's parts (e.g., proteins, receptors, and cell types) but also to the tissues and organs involved in the clinical condition under consideration. Organs such as bone and the immune systems share a variety of molecules, such as cytokines, transcription factors, and relevant signalling molecules. At the cellular level, immune cells communicate by humoral factors to cells of the bone, the endocrine, gastrointestinal, and nervous systems. In fact, upon activation of the immune system, a variety of molecules including cytokines are released that directly affect other organs, their crosstalk to other organs and the immune system itself.
The goal of this Research Topic is to summarize recent advances in the field of organ crosstalk with the immune system and/or with other organs in the presence of an activated immune system.
We welcome the submission of Review articles (comprehensive, systematic, or mini format), Original Research articles describing basic, translational and/or clinical studies, Methods articles, and Perspective or Opinion articles.
The articles should be focused on, but not limited to, the following topics:
• Specific organ responses to an activated immune system in the context of trauma, musculoskeletal diseases, or regenerative scenarios
• Organ crosstalk in the context of trauma, musculoskeletal diseases, or regenerative scenarios
• Main players on organ crosstalk, e.g. cytokines, chemokines, proteins, receptors, cells, etc.
• Immunotherapeutic approaches to selectively target dysregulated immune responses in trauma, musculoskeletal diseases, or regenerative scenarios
• In vitro models, e.g. organ-on-chip, organoids, etc. to study organ crosstalk in a compromised immune scenario
• Animal models to study organ crosstalk in a compromised immune scenario
• Clinical relevance of organ crosstalk in the context of trauma, musculoskeletal diseases, or regenerative scenarios