1) Background:
Alzheimer's disease (AD) and related dementias pose a significant global health challenge, affecting millions of individuals worldwide. Despite extensive research, the underlying mechanisms contributing to the development and progression of these neurodegenerative disorders remain incompletely understood. While the dysfunction in CSF clearance pathways is widely recognized as a contributing factor to the accumulation of toxic proteins such as amyloid-beta and tau in Alzheimer's disease, the exact waste removal mechanisms and pathways, including the role of the newly discovered glymphatic system, remain areas of active investigation and discussion. This discussion highlights the importance of further exploring CSF clearance mechanisms to unveil novel therapeutic strategies and early diagnostic biomarkers for AD.
2) Goal:
This Research Topic aims to address the current research gap by investigating CSF clearance mechanisms in Alzheimer's disease and related dementias. By exploring the multifaceted aspects of CSF clearance, we can shed light on the underlying mechanisms driving disease progression and identify potential targets for therapeutic intervention. Furthermore, understanding the relationship between CSF clearance and the accumulation of pathogenic proteins can aid in the development of diagnostic tools for early disease detection. Ultimately, this Research Topic's goal is to foster collaborative research efforts and promote advancements in our understanding of CSF dynamics in dementia.
3) Scope and Information for Authors:
Researchers contributing to this Research Topic are encouraged to explore various themes related to CSF clearance in Alzheimer's disease and related dementias. Topics of interest include, but are not limited to:
- Characterization of CSF clearance pathways and their impairment in AD
- Role of CSF biomarkers in early detection and prognosis
- Influence of vascular dysfunction on CSF clearance
- Neuroimaging techniques for studying CSF dynamics
- Therapeutic interventions targeting CSF clearance mechanisms
- Genetic and epigenetic factors modulating CSF clearance efficiency
We welcome original research articles, reviews, mini-reviews, and methodological papers that provide novel insights into the complex interactions between CSF clearance and dementia pathology. Manuscripts exploring the clinical relevance and translational potential of CSF clearance findings are highly encouraged. Together, we aim to advance our knowledge of CSF dynamics and pave the way for innovative strategies in dementia research and clinical management.
1) Background:
Alzheimer's disease (AD) and related dementias pose a significant global health challenge, affecting millions of individuals worldwide. Despite extensive research, the underlying mechanisms contributing to the development and progression of these neurodegenerative disorders remain incompletely understood. While the dysfunction in CSF clearance pathways is widely recognized as a contributing factor to the accumulation of toxic proteins such as amyloid-beta and tau in Alzheimer's disease, the exact waste removal mechanisms and pathways, including the role of the newly discovered glymphatic system, remain areas of active investigation and discussion. This discussion highlights the importance of further exploring CSF clearance mechanisms to unveil novel therapeutic strategies and early diagnostic biomarkers for AD.
2) Goal:
This Research Topic aims to address the current research gap by investigating CSF clearance mechanisms in Alzheimer's disease and related dementias. By exploring the multifaceted aspects of CSF clearance, we can shed light on the underlying mechanisms driving disease progression and identify potential targets for therapeutic intervention. Furthermore, understanding the relationship between CSF clearance and the accumulation of pathogenic proteins can aid in the development of diagnostic tools for early disease detection. Ultimately, this Research Topic's goal is to foster collaborative research efforts and promote advancements in our understanding of CSF dynamics in dementia.
3) Scope and Information for Authors:
Researchers contributing to this Research Topic are encouraged to explore various themes related to CSF clearance in Alzheimer's disease and related dementias. Topics of interest include, but are not limited to:
- Characterization of CSF clearance pathways and their impairment in AD
- Role of CSF biomarkers in early detection and prognosis
- Influence of vascular dysfunction on CSF clearance
- Neuroimaging techniques for studying CSF dynamics
- Therapeutic interventions targeting CSF clearance mechanisms
- Genetic and epigenetic factors modulating CSF clearance efficiency
We welcome original research articles, reviews, mini-reviews, and methodological papers that provide novel insights into the complex interactions between CSF clearance and dementia pathology. Manuscripts exploring the clinical relevance and translational potential of CSF clearance findings are highly encouraged. Together, we aim to advance our knowledge of CSF dynamics and pave the way for innovative strategies in dementia research and clinical management.
