Musculoskeletal regenerative medicine is a rapidly evolving field that focuses on the repair and regeneration of tissues such as cartilage and bone, which are often compromised due to injury or degenerative diseases. Despite the availability of various clinical interventions, these tissues have a limited capacity for self-repair, necessitating the development of innovative therapeutic strategies. Recent advancements have been made by integrating cell-based techniques with orthobiologics, which include biological materials like platelet-rich plasma (PRP) and growth factors, to enhance tissue regeneration. The latest studies have demonstrated the potential of combining stem cells with bioengineered scaffolds to create an optimal environment for tissue growth and integration. However, challenges remain in replicating the complex structure and function of native tissues, and there is a pressing need for further research to refine these approaches and improve clinical outcomes.This Research Topic aims to explore the most advanced protocols and procedures that can serve as tools to enhance the healing of musculoskeletal disorders. The primary objective is to provide a comprehensive overview of innovative strategies that can be translated into clinical practice, addressing the limitations of current therapies. Key questions include how to effectively combine cell-based and cell-free approaches, the role of orthobiologics in tissue repair, and the potential of emerging stem cell therapies in treating chondral pathologies.To gather further insights in the field of musculoskeletal regenerative medicine, we welcome articles addressing, but not limited to, the following themes:• Cell-free and cell-based approaches in cartilage repair and regeneration• Chondral pathologies and emerging stem cell therapies• Orthobiologics in chondral pathologies• Advancements in scaffolds for musculoskeletal repair• Role of subchondral bone in cartilage health and repairPlease note: systematic reviews are not accepted by Frontiers in Cell and Developmental Biology and, if in scope, should be submitted to Frontiers in Bioengineering and Biotechnology - Biomaterials
Musculoskeletal regenerative medicine is a rapidly evolving field that focuses on the repair and regeneration of tissues such as cartilage and bone, which are often compromised due to injury or degenerative diseases. Despite the availability of various clinical interventions, these tissues have a limited capacity for self-repair, necessitating the development of innovative therapeutic strategies. Recent advancements have been made by integrating cell-based techniques with orthobiologics, which include biological materials like platelet-rich plasma (PRP) and growth factors, to enhance tissue regeneration. The latest studies have demonstrated the potential of combining stem cells with bioengineered scaffolds to create an optimal environment for tissue growth and integration. However, challenges remain in replicating the complex structure and function of native tissues, and there is a pressing need for further research to refine these approaches and improve clinical outcomes.This Research Topic aims to explore the most advanced protocols and procedures that can serve as tools to enhance the healing of musculoskeletal disorders. The primary objective is to provide a comprehensive overview of innovative strategies that can be translated into clinical practice, addressing the limitations of current therapies. Key questions include how to effectively combine cell-based and cell-free approaches, the role of orthobiologics in tissue repair, and the potential of emerging stem cell therapies in treating chondral pathologies.To gather further insights in the field of musculoskeletal regenerative medicine, we welcome articles addressing, but not limited to, the following themes:• Cell-free and cell-based approaches in cartilage repair and regeneration• Chondral pathologies and emerging stem cell therapies• Orthobiologics in chondral pathologies• Advancements in scaffolds for musculoskeletal repair• Role of subchondral bone in cartilage health and repairPlease note: systematic reviews are not accepted by Frontiers in Cell and Developmental Biology and, if in scope, should be submitted to Frontiers in Bioengineering and Biotechnology - Biomaterials