Many studies have demonstrated the role of the overproduction of oxidative stress in the pathogenesis of various diseases such as cancer, insulin resistance, diabetes mellitus, cardiovascular diseases, and atherosclerosis. Many attempts to use antioxidants for the treatment of various diseases including the administration of both natural and synthetic antioxidants were made, however, this is still a controversial issue because the results of clinical trials have been inconsistent.
The original therapeutic approach to the antioxidant defense was the use of non-enzymatic antioxidants. Unfortunately, the results of these research were contentious since it was not clear which ROS should be targeted or because non-enzymatic antioxidants were not very effective at scavenging ROS. The ROS scavenging by antioxidant enzymes was suggested as the strategy for targeting oxidative stress by the use of chemical synthetic compounds designed to mimic the actions of antioxidant enzymes. The beneficial effect of SOD mimetics in the treatment of neurological disorders was demonstrated. Significant progress was also made in "green" extraction processes dedicated to the characterization and the assessment of bioactivity against different pathologies of various antioxidant compounds from plants. The present research topic covers a selection of original research and review articles related to the recent advances in the use of natural and synthetic antioxidants in targeting oxidative stress in human pathology.
Original Research articles and Reviews are welcome, including but not limited to the following contents:
• Natural and synthetic antioxidants: beneficial and detrimental effects on health
• Therapeutical application of antioxidant enzyme mimetics
• Therapeutic effect of plant extracts
• Dietary antioxidants
• Antioxidant therapeutic strategies
• The role of antioxidants in the prevention of chronic disease
Keywords:
antioxidants, oxidative stress, ROS, therapeutic strategies, chronic disease
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Many studies have demonstrated the role of the overproduction of oxidative stress in the pathogenesis of various diseases such as cancer, insulin resistance, diabetes mellitus, cardiovascular diseases, and atherosclerosis. Many attempts to use antioxidants for the treatment of various diseases including the administration of both natural and synthetic antioxidants were made, however, this is still a controversial issue because the results of clinical trials have been inconsistent.
The original therapeutic approach to the antioxidant defense was the use of non-enzymatic antioxidants. Unfortunately, the results of these research were contentious since it was not clear which ROS should be targeted or because non-enzymatic antioxidants were not very effective at scavenging ROS. The ROS scavenging by antioxidant enzymes was suggested as the strategy for targeting oxidative stress by the use of chemical synthetic compounds designed to mimic the actions of antioxidant enzymes. The beneficial effect of SOD mimetics in the treatment of neurological disorders was demonstrated. Significant progress was also made in "green" extraction processes dedicated to the characterization and the assessment of bioactivity against different pathologies of various antioxidant compounds from plants. The present research topic covers a selection of original research and review articles related to the recent advances in the use of natural and synthetic antioxidants in targeting oxidative stress in human pathology.
Original Research articles and Reviews are welcome, including but not limited to the following contents:
• Natural and synthetic antioxidants: beneficial and detrimental effects on health
• Therapeutical application of antioxidant enzyme mimetics
• Therapeutic effect of plant extracts
• Dietary antioxidants
• Antioxidant therapeutic strategies
• The role of antioxidants in the prevention of chronic disease
Keywords:
antioxidants, oxidative stress, ROS, therapeutic strategies, chronic disease
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.