The term „OxInflammation” has been coined to describe the vicious cycle that connects oxidative stress and inflammation. Oxidative stress results from overproduction of Reactive Oxygen Species (ROS) and diminished antioxidant defenses and it can be either cause or result of inflammation. Evidence indicated that low-grade chronic inflammation and oxidative stress co-exist in many chronic diseases like metabolic, cardiovascular, chronic kidney disease etc. It is believed that the cooccurrence of oxidative stress and inflammation can contribute to the initiation, development, and exacerbation of various chronic diseases. This disturbance may also affect the quality of animal-derived food products.
Although the use of oxinflammation markers in veterinary medicine has a growing interest, their clinical application is very limited due to numerous challenges (mentioned later in the text), indicating the need for in-depth research on these aspects.
Despite there are animal studies showing changes in oxinflammation markers in certain diseases, only a few have addressed how these processes are actually link with the developing of the disease and how much is a consequence of the disease itself. Additionally, comparison of these results is very challenging due to the variety of avaible options especially for oxidant/antixidant markers and uncertainty about what exactly each marker measures.
There are also many unvalidated assays in veterinary medicine which, together with the factors mentioned above, make it difficult to interpret the results accurately.
It should be kept in mind that the use of oxidant/antioxidant markers is poorly described in some species, especially exotic ones. Therefore, it should be determined first reference range in health population in order to set threshold values for pathological conditions.
Therefore, our goal is to present novel findings related to the identification and validation of oxinflammation markers in different animal species that would open a new perspective for their clinical application.
We cordially invite colleagues to contribute in this research topics their original research articles, and reviews including but not limited to the following topics:
● Investigation/validation new oxidative biomarkers in multiple species
● Investigation the role of oxidation and inflammation in the pathogenesis of specific diseases.
● Clinical trials with anti-oxidant supplementation to assess if it can improve the outcome or the clinical signs.
● Investigation on the role of oxidation in diagnosis, prognosis, and monitoring the efficacy of therapy
Keywords:
oxyinflammation, antioxidants, inflammatory mediators, low-grade inflammatory process, immune system, acute phase proteins, biomarkers
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
The term „OxInflammation” has been coined to describe the vicious cycle that connects oxidative stress and inflammation. Oxidative stress results from overproduction of Reactive Oxygen Species (ROS) and diminished antioxidant defenses and it can be either cause or result of inflammation. Evidence indicated that low-grade chronic inflammation and oxidative stress co-exist in many chronic diseases like metabolic, cardiovascular, chronic kidney disease etc. It is believed that the cooccurrence of oxidative stress and inflammation can contribute to the initiation, development, and exacerbation of various chronic diseases. This disturbance may also affect the quality of animal-derived food products.
Although the use of oxinflammation markers in veterinary medicine has a growing interest, their clinical application is very limited due to numerous challenges (mentioned later in the text), indicating the need for in-depth research on these aspects.
Despite there are animal studies showing changes in oxinflammation markers in certain diseases, only a few have addressed how these processes are actually link with the developing of the disease and how much is a consequence of the disease itself. Additionally, comparison of these results is very challenging due to the variety of avaible options especially for oxidant/antixidant markers and uncertainty about what exactly each marker measures.
There are also many unvalidated assays in veterinary medicine which, together with the factors mentioned above, make it difficult to interpret the results accurately.
It should be kept in mind that the use of oxidant/antioxidant markers is poorly described in some species, especially exotic ones. Therefore, it should be determined first reference range in health population in order to set threshold values for pathological conditions.
Therefore, our goal is to present novel findings related to the identification and validation of oxinflammation markers in different animal species that would open a new perspective for their clinical application.
We cordially invite colleagues to contribute in this research topics their original research articles, and reviews including but not limited to the following topics:
● Investigation/validation new oxidative biomarkers in multiple species
● Investigation the role of oxidation and inflammation in the pathogenesis of specific diseases.
● Clinical trials with anti-oxidant supplementation to assess if it can improve the outcome or the clinical signs.
● Investigation on the role of oxidation in diagnosis, prognosis, and monitoring the efficacy of therapy
Keywords:
oxyinflammation, antioxidants, inflammatory mediators, low-grade inflammatory process, immune system, acute phase proteins, biomarkers
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.