About this Research Topic
Enzyme catalysis is an inherently dynamic process: distances between atoms change during enzyme-catalyzed formation and breakage of bonds as a function of time. Many enzymes are also known to undergo a number of conformational changes during their catalytic cycle. These conformational fluctuations can be important for substrate selectivity, catalysis and interactions with regulatory partners. This Research Topic collection intends to elucidate the amazing repertoire of conformational motions undertaken by enzymes, across many orders of lengths and timescales. This Research Topic will highlight the many experimental and computational approaches to studying enzyme structural dynamics, how various motions may be important for enzyme function and how this information can be leveraged towards controlling enzyme function. Understanding enzyme structural dynamics can also give insight into the molecular evolution of catalytic machinery and provide new avenues towards the next generation of enzyme catalysts.
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