Research Topic

Structural Dynamics of Enzymes

About this Research Topic

Enzyme catalysis is an inherently dynamic process: distances between atoms change during enzyme-catalyzed formation and breakage of bonds as a function of time. Many enzymes are also known to undergo a number of conformational changes during their catalytic cycle. These conformational fluctuations can be important for substrate selectivity, catalysis and interactions with regulatory partners. This Research Topic collection intends to elucidate the amazing repertoire of conformational motions undertaken by enzymes, across many orders of lengths and timescales. This Research Topic will highlight the many experimental and computational approaches to studying enzyme structural dynamics, how various motions may be important for enzyme function and how this information can be leveraged towards controlling enzyme function. Understanding enzyme structural dynamics can also give insight into the molecular evolution of catalytic machinery and provide new avenues towards the next generation of enzyme catalysts.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Enzyme catalysis is an inherently dynamic process: distances between atoms change during enzyme-catalyzed formation and breakage of bonds as a function of time. Many enzymes are also known to undergo a number of conformational changes during their catalytic cycle. These conformational fluctuations can be important for substrate selectivity, catalysis and interactions with regulatory partners. This Research Topic collection intends to elucidate the amazing repertoire of conformational motions undertaken by enzymes, across many orders of lengths and timescales. This Research Topic will highlight the many experimental and computational approaches to studying enzyme structural dynamics, how various motions may be important for enzyme function and how this information can be leveraged towards controlling enzyme function. Understanding enzyme structural dynamics can also give insight into the molecular evolution of catalytic machinery and provide new avenues towards the next generation of enzyme catalysts.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

26 January 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

26 January 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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