Infertility remains as a concerning and challenging health issue worldwide, mostly due to the rises of infertility cases and the fact that a significant percentage of these are classified as idiopathic. Moreover, even in some cases where the ethology is understood, the underlying molecular mechanisms remain unclear. Gametogenesis and gamete function are very complex processes, since gametes and reproductive tissues are regulated at the hormonal, metabolic, genetic, and epigenetic level. For instance, lifestyle factors, such as diet and sedentarism, or exposure to drugs, pollutants, or endocrine disrupting chemicals are known factors that can compromise fertility. Understanding the molecular mechanisms underlying fertility is essential for comprehending physiology and pathology, which is ultimately necessary not only for effectively diagnosing and treating infertility in both males and females, but also for the improvement or development of contraception methods. This research topic has the goal of compiling a collection of manuscripts that offer new insights into the molecular aspects, including metabolic, hormonal, genetic, or epigenetic factors, that regulate the intricate systems underlying fertility. We invite submissions of Reviews, Mini-Reviews and Original Articles on basic, clinical (excluding clinical trials), and translational research on novel molecular mechanisms responsible for male and female (in)fertility. Furthermore, innovative methodologies and experimental approaches aimed at unraveling the complexities of these phenomena are highly encouraged.This Research Topic will explore various aspects related to fertility. Subtopics may include but are not limited to:• Metabolic regulation of reproductive tissues, gametogenesis, and gamete function• Hormonal (dys)regulation of reproduction tissues• Signaling pathways involved in reproductive tissues, gametogenesis, and gamete function regulation• Genetic and epigenetic regulation of reproductive tissues, gametogenesis, and gamete function• Impact of non-communicable diseases, inflammation, and other pathological conditions on reproduction
Infertility remains as a concerning and challenging health issue worldwide, mostly due to the rises of infertility cases and the fact that a significant percentage of these are classified as idiopathic. Moreover, even in some cases where the ethology is understood, the underlying molecular mechanisms remain unclear. Gametogenesis and gamete function are very complex processes, since gametes and reproductive tissues are regulated at the hormonal, metabolic, genetic, and epigenetic level. For instance, lifestyle factors, such as diet and sedentarism, or exposure to drugs, pollutants, or endocrine disrupting chemicals are known factors that can compromise fertility. Understanding the molecular mechanisms underlying fertility is essential for comprehending physiology and pathology, which is ultimately necessary not only for effectively diagnosing and treating infertility in both males and females, but also for the improvement or development of contraception methods. This research topic has the goal of compiling a collection of manuscripts that offer new insights into the molecular aspects, including metabolic, hormonal, genetic, or epigenetic factors, that regulate the intricate systems underlying fertility. We invite submissions of Reviews, Mini-Reviews and Original Articles on basic, clinical (excluding clinical trials), and translational research on novel molecular mechanisms responsible for male and female (in)fertility. Furthermore, innovative methodologies and experimental approaches aimed at unraveling the complexities of these phenomena are highly encouraged.This Research Topic will explore various aspects related to fertility. Subtopics may include but are not limited to:• Metabolic regulation of reproductive tissues, gametogenesis, and gamete function• Hormonal (dys)regulation of reproduction tissues• Signaling pathways involved in reproductive tissues, gametogenesis, and gamete function regulation• Genetic and epigenetic regulation of reproductive tissues, gametogenesis, and gamete function• Impact of non-communicable diseases, inflammation, and other pathological conditions on reproduction