About this Research Topic
In the last 15 years, impulse control disorders and related complications have been well-recognized as a frequent finding in subjects with Parkinson’s disease. Moreover, the association with dopaminergic replacement therapy (i.e. dopamine agonists) may have an impact in the way these patients are treated. On the other hand, observational, neuroimaging and neurophysiological studies have expanded our understanding of this disorder pathophysiology. The association between reward systems, and novelty-seeking and decision-making behaviors, with impulsivity is of great interest.
The purpose of this Research Topic is to publish high-quality research papers as well as review articles addressing these symptoms. Aspects covered will include clinical observations such as risk factors, social and cultural differences, neuropsychiatric and cognitive features, impact on health-related quality of life and caregiver burden. Studies regarding treatment strategies such as dopamine agonist-sparing, continuous dopaminergic stimulation, transcranial magnetic stimulation, transcranial direct current stimulation, and deep brain stimulation will also be of great value. Head-to-head dopamine agonist comparisons or other interventional trials are also welcome.
Neurophysiological and neuropsychological studies assessing decision-making processes, risky decision-making, impulsiveness, reward sensitivity and reward-related decision making, gambling behavior will also be relevant.
Also, neuroimaging studies like functional magnetic resonance imaging or PET/SPECT studies aiding our understanding of these disorders are welcome. For example, studies assessing cortical thickness in fMRI, or pre- and post-synaptic uptake of dopaminergic radiotracers can broaden our understanding of the pathological pathways associated with these types of behavioral symptoms.
Finally, genetic studies assessing dopamine receptor (DRD2, ANKK1), N-methyl-D-aspartate 2B (GRIN2B) or COMT polymorphisms are encouraged. Articles concerning animal models of ICD that add to the current body of knowledge in PD will be particularly appreciated.
Potential topics include, but are not limited to: Impulse control disorders, punding, binge eating, pathological gambling, hypersexuality, other related disorders (hobbyism, internet abuse, video gaming), impulsivity and decision-making, novelty-seeking behaviors, dopamine dysregulation syndrome, dopamine agonist withdrawal syndrome.
The scope of the Research Topic should provide broad interest to readers since it spans movement disorder specialists, neurologists, psychiatrists, psychologists, geneticists, and basic researchers.
Keywords: Impulse control disorder, impulsivity, dopamine dysregulation syndrome, decision-making, novelty-seeking