About this Research Topic
Nuclei are essential for cardiac and skeletal muscle fibre growth. Their envelopes are not just structures acting as barriers between cytoplasm and chromatin. They have multiple functions, with most of them yet to be discovered. Key questions that remain to be answered are: how do these envelopes regulate myonuclear integrity, architecture, chromatin organisation and genome? How do they modulate mechanotransduction and subsequent protein transcription? How do mutations in proteins forming these envelopes induce a wide range of diseases including premature ageing and muscular dystrophies? With this understanding, new potential therapeutic interventions are likely to be developed. Hence, in the present research topic contributors are encouraged to submit reviews, mini-reviews, commentaries, perspectives and research articles dealing with the above questions.
Keywords: Lamin, Nesprin, Nuclear Lamina, Protein Transcription, Muscle Function