Research Topic

Autophagy in Autoimmunity

About this Research Topic

Autoimmune diseases are a major cause of morbidity and mortality worldwide and occur at a higher frequency in young adults and women than in men. It is increasingly recognized that the development of autoimmunity is strongly influenced by complex interactions between genetic predispositions and environmental triggers, implicating both innate and adaptive immune responses. More recently, findings from molecular, cell-based and animal studies suggest a pivotal role of autophagy in mediating a myriad of autoimmune diseases, including Systemic Lupus Erythematosus, Inflammatory Bowel Disease, Rheumatoid Arthritis, Psoriasis and Multiple Sclerosis. These findings have opened a window into improving our knowledge of the molecular pathways implicated in autoimmunity, and how these pathways can be therapeutically targeted in the coming years. Greater discourse among different researchers is required to further our understanding of the pathogenesis of autoimmunity. This Research Topic aims to co-ordinate a discussion on studies within the field that offer both broad and divergent insight into the role of autophagy in autoimmunity.

We welcome the submission of Original Research, Review, Mini-Review, Perspective and Commentary articles that include, but are not restricted to the following topics:

1. Genetic studies focusing on autophagy with functional significance.
2. Animal models targeting autophagy of human autoimmune diseases.
3. Cell biology studies highlighting the role of autophagy in autoimmunity.
4. Interventional study showing therapeutic value of autophagy in immune-related diseases.
5. Insightful perspectives on different views on the role of autophagy in autoimmunity and future directions.


Keywords: Autophagy, Autoimmunity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Autoimmune diseases are a major cause of morbidity and mortality worldwide and occur at a higher frequency in young adults and women than in men. It is increasingly recognized that the development of autoimmunity is strongly influenced by complex interactions between genetic predispositions and environmental triggers, implicating both innate and adaptive immune responses. More recently, findings from molecular, cell-based and animal studies suggest a pivotal role of autophagy in mediating a myriad of autoimmune diseases, including Systemic Lupus Erythematosus, Inflammatory Bowel Disease, Rheumatoid Arthritis, Psoriasis and Multiple Sclerosis. These findings have opened a window into improving our knowledge of the molecular pathways implicated in autoimmunity, and how these pathways can be therapeutically targeted in the coming years. Greater discourse among different researchers is required to further our understanding of the pathogenesis of autoimmunity. This Research Topic aims to co-ordinate a discussion on studies within the field that offer both broad and divergent insight into the role of autophagy in autoimmunity.

We welcome the submission of Original Research, Review, Mini-Review, Perspective and Commentary articles that include, but are not restricted to the following topics:

1. Genetic studies focusing on autophagy with functional significance.
2. Animal models targeting autophagy of human autoimmune diseases.
3. Cell biology studies highlighting the role of autophagy in autoimmunity.
4. Interventional study showing therapeutic value of autophagy in immune-related diseases.
5. Insightful perspectives on different views on the role of autophagy in autoimmunity and future directions.


Keywords: Autophagy, Autoimmunity


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

01 March 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..

Topic Editors

Loading..

Submission Deadlines

01 March 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top