About this Research Topic
Neurodegenerative diseases place a large emotional and economic burden on patients and society. With increasing health care expenditures among cognitively impaired elderly, identifying individuals at risk for developing dementia is of utmost importance for potential preventative and therapeutic strategies. Although genome-wide association studies (GWAS) have identified several genetic variants associated with increased risk for a number of neurodegenerative disorders, the underlying genetic architecture of dementia is still unknown. Furthermore, the relationship between genes associated with increased disease risk, underlying pathobiology and phenotypic manifestations of neurodegenerative diseases is poorly understood.
In this Research Topic across a range of manuscripts, we will assess the underlying genetic architecture of a number of neurodegenerative and neuropsychiatric diseases. We will focus on the relationship between genetics, gene expression and underlying phenotypic manifestations of the disease process including multimodal neuroimaging, fluid biomarkers and clinical markers of disease progression.
Keywords: Genetics, neurodegeneration, gene expression, dementia, genetic epidemiology
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