More than 3.5 billion people worldwide are enduring oral health issues. The complex oral microbial interactions are not only involved in oral diseases but also tightly related to overall human health. Oral health can affect the risk of at least 28 systemic noncommunicable diseases, such as cancer, cardiovascular disease, diabetes, stroke, Alzheimer's disease, etc. Oral microorganisms mainly exist in the form of oral biofilms. The microbial interactions are micrometer-scale manifestations of molecular-level interactions between different bacteria. For example, co-adhesion is crucial for the formation of multi-genus microbiota, while metabolic interactions occur between them. Both spatial organization and molecular interactions contribute to locating microorganisms in the microenvironment of oral biofilms. However, currently, limited studies have shown the impact of interactions between different microbial species in the oral cavity on the occurrence and development of diseases.The oral cavity can be colonized by more than 700 different species of microbes, including bacteria, archaea, fungi, viruses, and protists. The diversity of microbial species and the complexity of the host's internal environment often lead to unsatisfactory therapeutic effects and the inability to eradicate biofilms. The interactions between microorganisms provide more drug resistance and immune evasion. Therefore, it is necessary to further understand the interactions between microorganisms to deliver new strategies for inhibiting the development of pathogenic microorganisms and targeted clearance of biofilm infections.To present the most recent studies on the interactions between oral multispecies microbial biofilm, therefore understanding the developments and treatment in disease infection. In this Research Topic, we would like to include articles in the form of Original Research, Reviews, Opinions and Perspectives. We invite contributions that relate to, but are not limited to, the following topics:• The mechanism of interaction of oral microorganisms in the occurrence and development of diseases.• The mechanism of the mutual promotion or inhibition of oral multi-species microorganisms.• Methods to help decompose and eliminate the synergistic effects of biofilms.
More than 3.5 billion people worldwide are enduring oral health issues. The complex oral microbial interactions are not only involved in oral diseases but also tightly related to overall human health. Oral health can affect the risk of at least 28 systemic noncommunicable diseases, such as cancer, cardiovascular disease, diabetes, stroke, Alzheimer's disease, etc. Oral microorganisms mainly exist in the form of oral biofilms. The microbial interactions are micrometer-scale manifestations of molecular-level interactions between different bacteria. For example, co-adhesion is crucial for the formation of multi-genus microbiota, while metabolic interactions occur between them. Both spatial organization and molecular interactions contribute to locating microorganisms in the microenvironment of oral biofilms. However, currently, limited studies have shown the impact of interactions between different microbial species in the oral cavity on the occurrence and development of diseases.The oral cavity can be colonized by more than 700 different species of microbes, including bacteria, archaea, fungi, viruses, and protists. The diversity of microbial species and the complexity of the host's internal environment often lead to unsatisfactory therapeutic effects and the inability to eradicate biofilms. The interactions between microorganisms provide more drug resistance and immune evasion. Therefore, it is necessary to further understand the interactions between microorganisms to deliver new strategies for inhibiting the development of pathogenic microorganisms and targeted clearance of biofilm infections.To present the most recent studies on the interactions between oral multispecies microbial biofilm, therefore understanding the developments and treatment in disease infection. In this Research Topic, we would like to include articles in the form of Original Research, Reviews, Opinions and Perspectives. We invite contributions that relate to, but are not limited to, the following topics:• The mechanism of interaction of oral microorganisms in the occurrence and development of diseases.• The mechanism of the mutual promotion or inhibition of oral multi-species microorganisms.• Methods to help decompose and eliminate the synergistic effects of biofilms.