Research Topic

From Structure to Function - The Interplay between Cell Adhesion Molecules and the Cytoskeleton

About this Research Topic

Transformation of transient cell-to- cell contacts into stable functional contacts is a process required for several cellular functions, including cell migration, recognition, and cell-to- cell communication. It is accompanied by significant changes in the molecular composition and structure of these contacts.
Transient contacts are stabilized by cell adhesion molecules. The extracellular domains of the various families of these cell surface glycoproteins mediate cellular interactions by forming homophilic and heterophilic adhesive bonds with cell adhesion molecules on other cells or with the components of the extracellular matrix. In addition, their intracellular domains interact with the cytoskeleton components, which accumulate at the contacts and transform, maintain and regulate the contact structure. The interaction between cell adhesion molecules and the cytoskeleton is bidirectional. Cell adhesion molecules modulate the cytoskeleton by acting through various enzymes, whereas the cytoskeleton regulates levels of the cell adhesion molecules at the contacts.

The aim of this Research Topic is to cover the molecular mechanisms involved in remodelling of cell adhesion and the cytoskeleton during cell-to- cell contact formation, maturation and maintenance including the assembly of the macromolecular complexes at the contact sites, activation of the signalling across the cell surface membrane, cytoskeleton remodelling and gene expression modulation. The scope of the Research Topic in regards to cellular systems will be broad, to encompass different biological processes, such as regulation of epithelial organization, wound healing, neuronal synapses or immunological synapses


Keywords: Cell adhesion, cytoskeleton, intracellular signaling, cellular interactions, synapse


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Transformation of transient cell-to- cell contacts into stable functional contacts is a process required for several cellular functions, including cell migration, recognition, and cell-to- cell communication. It is accompanied by significant changes in the molecular composition and structure of these contacts.
Transient contacts are stabilized by cell adhesion molecules. The extracellular domains of the various families of these cell surface glycoproteins mediate cellular interactions by forming homophilic and heterophilic adhesive bonds with cell adhesion molecules on other cells or with the components of the extracellular matrix. In addition, their intracellular domains interact with the cytoskeleton components, which accumulate at the contacts and transform, maintain and regulate the contact structure. The interaction between cell adhesion molecules and the cytoskeleton is bidirectional. Cell adhesion molecules modulate the cytoskeleton by acting through various enzymes, whereas the cytoskeleton regulates levels of the cell adhesion molecules at the contacts.

The aim of this Research Topic is to cover the molecular mechanisms involved in remodelling of cell adhesion and the cytoskeleton during cell-to- cell contact formation, maturation and maintenance including the assembly of the macromolecular complexes at the contact sites, activation of the signalling across the cell surface membrane, cytoskeleton remodelling and gene expression modulation. The scope of the Research Topic in regards to cellular systems will be broad, to encompass different biological processes, such as regulation of epithelial organization, wound healing, neuronal synapses or immunological synapses


Keywords: Cell adhesion, cytoskeleton, intracellular signaling, cellular interactions, synapse


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

15 January 2018 Abstract
15 June 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

15 January 2018 Abstract
15 June 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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