Editors
3
Impact
Loading...
9,055 views
59 citations
Mini Review
14 January 2019
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules
Marius Volker Dannappel
2 more and 
Ron Firestein

CDK8 and its paralog, CDK19, collectively termed ‘Mediator Kinase,’ are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and developmental programming. CDK8 and CDK19 are incorporated, in a mutually exclusive manner, as part of a 4-protein complex called the Mediator kinase module. This module reversibly associates with the Mediator, a 26 subunit protein complex that regulates RNA Polymerase II mediated gene expression. As part of this complex, the Mediator kinases have been implicated in diverse process such as developmental signaling, metabolic homeostasis and in innate immunity. In recent years, dysregulation of Mediator kinase module proteins, including CDK8/19, has been implicated in the development of different human diseases, and in particular cancer. This has led to intense efforts to understand how CDK8/19 regulate diverse biological outputs and develop Mediator kinase inhibitors that can be exploited therapeutically. Herein, we review both context and function of the Mediator kinases at a molecular, cellular and animal level. In so doing, we illuminate emerging concepts underpinning Mediator kinase biology and highlight certain aspects that remain unsolved.

16,161 views
68 citations
6,601 views
43 citations
Recommended Research Topics
Frontiers Logo

Frontiers in Cell and Developmental Biology

Novel Insights into the Multifaceted Mitotic Kinases
Edited by Sabine Elowe, Anna Santamaria
93.9K
views
16
authors
8
articles
Frontiers Logo

Frontiers in Cell and Developmental Biology

Unexpected Consequences of Telomere and Telomerase Dysfunction
Edited by Catarina M Henriques, Maria Luisa Cayuela
48.1K
views
13
authors
3
articles
Frontiers Logo

Frontiers in Cell and Developmental Biology

Chromosome Bi-orientation, Tension and the Spindle-Assembly Checkpoint
Edited by Scott C. Schuyler, Todd Stukenberg, Mohan Gupta
17.9K
views
18
authors
5
articles
Frontiers Logo

Frontiers in Cell and Developmental Biology

Reviews and Advances in our Understanding of the Relationship between the Cell Cycle, DNA Damage and Cancer
Edited by Damien D'Amours, Lisa A. Porter, Daniel Leslie Fisher, Brian Gabrielli
17.7K
views
29
authors
6
articles
Frontiers Logo

Frontiers in Cell and Developmental Biology

Molecular Networks Controlling Cell Growth and Cell Division Cycle in Cancers
Edited by Pavel Kraikivski, Anand Banerjee, Teeraphan Laomettachit
Deadline
15 Aug 2025
Submit