About this Research Topic
Incidence of pulmonary disease caused by nontuberculous mycobacteria (NTM) such as Mycobacterium abscessus and M. avium is increasing at an alarming rate, surpassing tuberculosis (TB) in many countries. Treatment duration is extremely long, usually lasting for 1-2 years, with a macrolides-based multi-drug regimen. However, the results are in general disappointing with low sputum conversion rates, resembling that of XDR-TB. There is an urgent need for improved diagnostics and more efficacious therapeutics, for a better understanding of epidemiology, host-pathogen interaction and pathophysiology of the bacteria. In this research topic, we plan to bring together experts from a range of disciplines addressing current status, gaps and needs, and new developments in all NTM-relevant research areas.
Specifically, this Research Topic will include various aspects of NTM such as disease presentation, pathology, diagnosis, treatment, drug resistance, epidemiology, genomics, host-pathogen interaction, immunology, vaccine development, pathophysiology of bacteria, drug discovery, animal models, and clinical drug development.
Keywords: Non-TB mycobacteria, NTM, drug resistance, drug discovery, host-pathogen interaction
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