Pulmonary disease caused by non-tuberculous mycobacteria (NTM), relatives of Mycobacterium tuberculosis, is increasing at an alarming rate, surpassing tuberculosis (TB) in many countries. Patients suffering from chronic pulmonary diseases, including Cystic Fibrosis and Chronic Obstructive Pulmonary Disease, are particularly susceptible to NTM infections. These infections are difficult to diagnose and present significant challenges for treatment. The environmental reservoir of the infectious agents and an incomplete understanding of what makes individuals susceptible to infection complicates preventive approaches. Considering the rising incidence and likely underreporting of these infections, a clear understanding of the barriers to diagnosis, treatment and prevention, and focused research on the pathobiology and microbiology of NTMs and new methods to combat them is urgently needed.
Recognizing this emerging new health threat and the complex nature of these infections, the National Institute of Allergy and Infectious Diseases organized the first NTM-focused workshop “Advancing Translational Science for Pulmonary NTM Infections” in Rockville, MD, in September 2017. This workshop, bringing together scientists and physicians from the United States and abroad, identified gaps in fundamental biological and epidemiological research and mapped out possible approaches for targeted translational science to expedite improvements in detection and care (Daniel-Wayman et al., 2018). The gathering not only generated increased awareness of this new health issue, it also brought together research disciplines and investigators from across the world who previously had few opportunities to interact, and kick-started new collaborative research activities. Momentum created during this workshop also resulted in the Research Topic “NTM—The New Uber-Bugs.”
NTM basic and translational research are still in their infancy with many questions remaining to understand the biological diversity of the infecting pathogens, their similarities and differences and how these affect pathobiology, transmission, and response to therapy. Furthermore, depending on where NTM infections occur globally, different species of NTM predominate, making rapid diagnostics that can speciate mycobacteria a necessity. This acute need to reduce the biological uncertainties around NTM pulmonary disease by increasing research efforts reminds of the state of knowledge TB research was facing two decades ago. Despite an initial research void in the TB field during the last quarter of the twentieth century, in part driven by the absence of molecular tools and animal models to study this difficult pathogen, significant progress has been achieved since the early 2000s. Knowledge and tools developed for the study of TB disease and approaches and technologies and platforms that have been applied to TB product development can be leveraged for NTM research. For instance, chemical entities with activity against Mycobacterium tuberculosis that have been generated in TB screening campaigns can quickly also be tested against NTM and may facilitate repositioning and repurposing of chemical leads and create a complementary approach to de novo drug discovery. By exploiting strategies and tools developed for TB, together with increasing research and product development focused on high-priority NTM species, we believe that significant medical advances for NTM diseases will be achieved in the medium term.
The present Research Topic, “NTM—The New Uber-Bugs” compiles contemporary results and insights from a group of leading researchers into the high-priority research area of NTM infections. It also highlights that in order to truly understand the diverse nature of these infections and their impact on human health, more thorough trans-national collaborations and data sharing will be important. We would like to thank the reviewers for their many thoughtful and insightful comments, and the authors for their excellent contributions. We hope that this collection of manuscripts will stimulate much-needed discussions and research activities on the challenging lung disease caused by the diverse group of pathogens called non-tuberculous mycobacteria.
Statements
Author contributions
All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.
Funding
TD holds a Toh Chin Chye Visiting Professorship at the Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore. His work is supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Numbers R01AI132374 and 2R01AI106398-05 and by the Cystic Fibrosis Foundation under Award Number DICK17XX00. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the Cystic Fibrosis Foundation.
Acknowledgments
We are grateful to all the authors and reviewers for their contributions to this Research Topic.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
1
Daniel-WaymanS.AbateG.BarberD. L.BermudezL. E.ColerR. N.CynamonM. H.et al. (2018). Advancing translational science for pulmonary nontuberculous mycobacterial infections. a road map for research. Am. J. Respir. Crit. Care Med.199, 947–951. 10.1164/rccm.201807-1273PP
Summary
Keywords
non-tuberculous mycobacteria, environmental mycobacteria, lung disease, repositioning, from biology to solutions
Citation
Dartois V, Sizemore C and Dick T (2019) Editorial: NTM—The New Uber-Bugs. Front. Microbiol. 10:1299. doi: 10.3389/fmicb.2019.01299
Received
23 April 2019
Accepted
24 May 2019
Published
12 June 2019
Volume
10 - 2019
Edited by
Axel Cloeckaert, Institut National de la Recherche Agronomique (INRA), France
Reviewed by
Philippe Lanotte, Université de Tours, France
Updates
Copyright
© 2019 Dartois, Sizemore and Dick.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Thomas Dick thomas.dick@HMH-CDI.org
This article was submitted to Antimicrobials, Resistance and Chemotherapy, a section of the journal Frontiers in Microbiology
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