About this Research Topic
Respiratory viruses include important RNA and DNA pathogens, specifically the Respiratory Syncytial Virus (RSV) A/B, the Influenza Virus (IFV) A/B, the Parainfluenza Virus (PIV) 1-3, the Human Corona-virus (HCoV), the Human Metapneumovirus (HMPV), the Human Rhinovirus (HRV), the Cytomegalovirus (CMV), the Human Bocavirus (HBoV), and the Human Adenovirus (HAdV). These viruses have been implicated in both upper and lower respiratory tract infections which can be associated with considerable morbidity even in immunocompetent individuals. Community-acquired pneumonia (CAP) caused by the viruses is an important respiratory disease and the fifth leading cause of mortality in Europe. In developing countries with close-quartered and/or vulnerable population, CAP poses an even greater risk. Other well documented clinical manifestations include, for example, initiation and acute exacerbation of asthma both in children and adults or bronchiolitis in young infants. In immunocompromised patients such as hematopoietic stem cell transplant (HSCT) or solid organ transplant (SOT) recipients, respiratory viral infections cause life-threatening diseases associated with high mortality. Due to their clinical importance and the limited antiviral treatment options, these viruses pose major clinical challenges.
This Research Topic in Frontiers in Microbiology will feature authoritative articles focusing on select human respiratory viruses and addressing genomic, epidemiological, diagnostic and therapeutic aspects of infections caused by these pathogens. Leading researchers and clinicians are encouraged to present articles and reviews providing state-of-the-art information on respiratory viral infections with a particular focus on human adenoviruses which represent one of the most burning issues in the immunocompromised patient setting.
Keywords: Genomics, Epidemiology, Diagnostics, Management, Human Respiratory Viruses