About this Research Topic
T cell differentiation and effector function are shaped by the integration of different signals from the environment. These signals are orchestrated through a variety of signaling receptors including the T cell receptor, activating (co-stimulatory molecules or cytokines) and inhibitory (checkpoint) receptors. Thus, the modulation of external signals could impact on the development or function of effector and/or regulatory T (Treg) cells. In pre-clinical human or animal studies, the manipulation of T cell function has been attempted via numerous different approaches. These include (i) immune checkpoint blockade (PD-1, PD-L1, Tim3 and/or CTLA-4 among others), (ii) alterations in metabolic pathways and (iii) the utilization of biological agents such as hormones, cytokines or neutralizing antibodies. Overall, these therapies aim to convert a pathological immune response into a protective one via the control or reprogramming of specific T cells subsets.
This Research Topic aims to provide a comprehensive overview of the diverse strategies focused on modulating T cell function that aim to prevent or revert pathological immune responses against pathogens and self-antigens. We welcome the submission of Reviews, Mini-Reviews and Original Research articles that discuss a diversity of approaches aimed at modulating T cell responses in autoimmunity and infection, and how they have been or could be used to design novel immunotherapies.
Keywords: T cell modulation, Autoimmunity, Infection, Immune checkpoint, T cell, Treg
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