About this Research Topic
Enhanced adiposity, a chronic low-grade inflammatory condition, represents a major risk factor for colorectal cancer (CRC) as well as an important indicator of tumor survival, prognosis and recurrence. Obesity-associated inflammation and the benefits of anti-inflammatory drugs in lowering CRC risk and in delaying the development of intestinal tumors, provide compelling evidence for a link among inflammation, obesity and CRC. The inflammatory status and fatty acid (FA) profile of adipose tissue (AT), an endocrine organ that regulates metabolic and immune processes, is now emerging as an important determinant in carcinogenesis. FA profile closely reflects dietary intake and may impact metabolic, inflammatory and immune profiles. Dietary patterns have been directly associated with increased or decreased CRC risk and epidemiological studies have highlighted the importance of physical activity and muscle function in cancer risk or prevention.
Importantly, gender-specific disparities related to genetic and lifestyle factors are known CRC risk factors, but represent still neglected aspects of CRC management. Gender differences have been observed not only in tumor incidence, localization and response to therapy but also in body fat storage/distribution and lifestyle. Given the steady rise of both obesity and cancer worldwide, understanding the link between obesity-related inflammation and cancer etiology is an essential undertaking. A critical barrier to progress in the field is the still poor knowledge of the molecular and cellular pathways perturbed under inflammatory and cancer conditions and of how they are influenced by diet and physical exercise. Dissecting this interconnection from a gender and lifestyle perspective has the potential to improve our comprehension of important elements in CRC development and management.
This Research Topic will provide a comprehensive overview on the impact of diet and physical exercise on the inflammatory status of adipose tissue in health and disease states, such as CRC, in a gender perspective. We welcome the submission of Review, Mini-Review and Original Research articles covering, but not limited to, the following topics:
1. Adipose tissue inflammation and diet/physical exercise.
2. Gender-specific aspects of lifestyle, inflammation and CRC.
3. Physical activity and muscle function in CRC prevention/promotion.
4. Dietary profiles and CRC.
5. Lifestyle-based CRC prevention strategies.
6. Obesity-associated biomarker patterns.
7. Obesity-associated inflammation and CRC.
8. Adipose tissue microenvironment and cancer.
9. Obesity, gut microbiota and cancer.
Keywords: Diet, Obesity, Colorectal cancer, Inflammation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.