Research Topic

Obesity and Diabetes: Implications for Brain-Immunometabolism

  • Submission closed.

About this Research Topic

Obesity is a major worldwide health problem, reached epidemic proportions that affects both developed and developing countries. Obesity increases the risk for a wide metabolic conditions including type 2 diabetes. Additionally, a relationship between obesity, diabetes and cognitive function, as well as risk ...

Obesity is a major worldwide health problem, reached epidemic proportions that affects both developed and developing countries. Obesity increases the risk for a wide metabolic conditions including type 2 diabetes. Additionally, a relationship between obesity, diabetes and cognitive function, as well as risk of dementias have come to attention. The link between these pathologies is the activation of the inflammatory process.

Obesity is considered as a chronic low grade inflammatory disease that affects numerous tissues including the brain. The consumption of large amounts of dietary fats, particularly saturated fatty acids can impair hypothalamic neuronal metabolism and circuitries that control whole-body energy homeostasis, consequently leading to obesity. Homeostatic control of brain metabolism is essential for neuronal activity. Neuroendocrine signals play a major role in the regulation of brain metabolism and also peripheral energy balance. Brain inflammation is a major cause for brain metabolic dysfunction and it is known to impair the control of whole-body energy homeostasis and also brain activity in several metabolic and neurodegenerative disorders. Metabolic diseases, inflammation, and brain diseases are likely linked, however a clear mechanistic understanding has remained elusive.

This Research Topic aims to publish cutting edge articles on the neurometabolic changes in the brain induced by inflammatory processes associated with obesity and chronic metabolic disorders. We will welcome original research manuscripts and review articles on, but not limited to, the following topics:

- Neuroinflammation and neuronal metabolism
- Brain metabolism in obesity
- Brain metabolism in diabetes
- Obesity induced dementia diseases- inflammatory mechanisms
- Neuroinflammation and neuronal metabolism
- Mitochondrial dysfunction in neuroinflammation


Keywords: Brain Metabolism, Obesity, Diabetes, Hyperglycemia, Saturated fatty acids


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top