Research Topic

Dissecting Metastatic Disease: The Paradigm of Cancer of Unknown Primary Origin

About this Research Topic

A fundamental axiom in cancer research describes tumorigenesis as a multistep process in which genetic events that activate oncogenes or inactivate tumor suppressor genes are sequentially acquired, frequently in a genetically unstable background. Despite this theoretical concern, experimental evidence and clinical examples have shown that the multistage process of carcinogenesis is not a simplistic sum of effects deriving from activated oncogenes or inactivated tumor suppressor genes, but is a more complex scenario. Growing evidence suggest that dissemination of primary cancer cells to distant sites might be an early event. Thus, Cancer of Unknown Primary (CUP) represent an intriguing and paradigmatic model of the biological process that drives a hyper-aggressive malignant phenotype.

We welcome manuscripts addressing the following themes:

• Genetic basis of CUPs
• Pathological issues and definition
• Tracking metastatic disease
• Mathematical and physical dynamics of metastatic spreading
• Clinical management of CUPs
• Clinical and molecular epidemiology of CUPs
• Lineage evolution and tracking


Keywords: Metastasis, genetics, lineage-tracing, stem cell, actionable target


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

A fundamental axiom in cancer research describes tumorigenesis as a multistep process in which genetic events that activate oncogenes or inactivate tumor suppressor genes are sequentially acquired, frequently in a genetically unstable background. Despite this theoretical concern, experimental evidence and clinical examples have shown that the multistage process of carcinogenesis is not a simplistic sum of effects deriving from activated oncogenes or inactivated tumor suppressor genes, but is a more complex scenario. Growing evidence suggest that dissemination of primary cancer cells to distant sites might be an early event. Thus, Cancer of Unknown Primary (CUP) represent an intriguing and paradigmatic model of the biological process that drives a hyper-aggressive malignant phenotype.

We welcome manuscripts addressing the following themes:

• Genetic basis of CUPs
• Pathological issues and definition
• Tracking metastatic disease
• Mathematical and physical dynamics of metastatic spreading
• Clinical management of CUPs
• Clinical and molecular epidemiology of CUPs
• Lineage evolution and tracking


Keywords: Metastasis, genetics, lineage-tracing, stem cell, actionable target


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 March 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 March 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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