About this Research Topic
A fundamental axiom in cancer research describes tumorigenesis as a multistep process in which genetic events that activate oncogenes or inactivate tumor suppressor genes are sequentially acquired, frequently in a genetically unstable background. Despite this theoretical concern, experimental evidence and clinical examples have shown that the multistage process of carcinogenesis is not a simplistic sum of effects deriving from activated oncogenes or inactivated tumor suppressor genes, but is a more complex scenario. Growing evidence suggest that dissemination of primary cancer cells to distant sites might be an early event. Thus, Cancer of Unknown Primary (CUP) represent an intriguing and paradigmatic model of the biological process that drives a hyper-aggressive malignant phenotype.
We welcome manuscripts addressing the following themes:
• Genetic basis of CUPs
• Pathological issues and definition
• Tracking metastatic disease
• Mathematical and physical dynamics of metastatic spreading
• Clinical management of CUPs
• Clinical and molecular epidemiology of CUPs
• Lineage evolution and tracking
Keywords: Metastasis, genetics, lineage-tracing, stem cell, actionable target
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