About this Research Topic
A large body of evidence has well documented that metabolic defects, such as islet β-cell dysfunction, reduced incretin response, and impaired autonomic function, are commonly observed in patients with type 2 diabetes. They may drive the development of type 2 diabetes and contribute to the increased risk of diabetes-related complications. In this Research Topic, we aim to promote the latest research in physiology that focuses on the metabolic defects underlying the onset of type 2 diabetes or its complications, with direct or indirect connections to the clinical applications and/or practice. We also plan to advance our knowledge about the effectiveness of lifestyle modifications, such as increased physical activity or reduced sedentary time on managing type 2 diabetes. We will focus on the mechanisms that mediate alterations of metabolic defects induced by lifestyle modifications, wishing to provide interactions and/or communications between basic and clinical researchers. Manuscripts in forms of original articles, reviews, commentaries, or perspectives are welcome to this Research Topic.
Keywords: Diabetes, metabolic defects, β-cell function, dietary intervention, physical exercise
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