About this Research Topic
Type 2 diabetes is on its rise and has become a widespread epidemic in recent years. It is one of the leading causes of cardiovascular disease, blindness, end stage renal failure, and nontraumatic lower limb amputations, leading to subsequently growing social and clinical burden globally. As a result, an enriched understanding of the pathogenesis of type 2 diabetes, along with attempts to sort out and carry out effective approaches to prevent or treat type 2 diabetes or its macro- and micro-vascular complications, are of paramount importance.
A large body of evidence has well documented that metabolic defects, such as islet β-cell dysfunction, reduced incretin response, and impaired autonomic function, are commonly observed in patients with type 2 diabetes. They may drive the development of type 2 diabetes and contribute to the increased risk of diabetes-related complications. In this Research Topic, we aim to promote the latest research in physiology that focuses on the metabolic defects underlying the onset of type 2 diabetes or its complications, with direct or indirect connections to the clinical applications and/or practice. We also plan to advance our knowledge about the effectiveness of lifestyle modifications, such as increased physical activity or reduced sedentary time on managing type 2 diabetes. We will focus on the mechanisms that mediate alterations of metabolic defects induced by lifestyle modifications, wishing to provide interactions and/or communications between basic and clinical researchers. Manuscripts in forms of original articles, reviews, commentaries, or perspectives are welcome to this Research Topic.
Keywords: Diabetes, metabolic defects, β-cell function, dietary intervention, physical exercise
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