Research Topic

Type 2 Diabetes Management: A Focus on Metabolic Defects

About this Research Topic

Type 2 diabetes is on its rise and has become a widespread epidemic in recent years. It is one of the leading causes of cardiovascular disease, blindness, end stage renal failure, and non­traumatic lower limb amputations, leading to subsequently growing social and clinical burden globally. As a result, an ...

Type 2 diabetes is on its rise and has become a widespread epidemic in recent years. It is one of the leading causes of cardiovascular disease, blindness, end stage renal failure, and non­traumatic lower limb amputations, leading to subsequently growing social and clinical burden globally. As a result, an enriched understanding of the pathogenesis of type 2 diabetes, along with attempts to sort out and carry out effective approaches to prevent or treat type 2 diabetes or its macro- and micro-vascular complications, are of paramount importance.

A large body of evidence has well documented that metabolic defects, such as islet β-cell dysfunction, reduced incretin response, and impaired autonomic function, are commonly observed in patients with type 2 diabetes. They may drive the development of type 2 diabetes and contribute to the increased risk of diabetes-related complications. In this Research Topic, we aim to promote the latest research in physiology that focuses on the metabolic defects underlying the onset of type 2 diabetes or its complications, with direct or indirect connections to the clinical applications and/or practice. We also plan to advance our knowledge about the effectiveness of lifestyle modifications, such as increased physical activity or reduced sedentary time on managing type 2 diabetes. We will focus on the mechanisms that mediate alterations of metabolic defects induced by lifestyle modifications, wishing to provide interactions and/or communications between basic and clinical researchers. Manuscripts in forms of original articles, reviews, commentaries, or perspectives are welcome to this Research Topic.


Keywords: Diabetes, metabolic defects, β-cell function, dietary intervention, physical exercise


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Submission Deadlines

23 October 2018 Manuscript
22 November 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

23 October 2018 Manuscript
22 November 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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