About this Research Topic
KININ2018CLE is the present version of the kinin meeting that occurs every three years. The aim of this meeting was to assemble scientists and clinicians involved in the field of bradykinin (kinins) and its related proteins (enzymes, cofactors, substrates, receptors, proteolytic systems, disease states, and developing therapies) for presentation of the latest ideas, research, drug development, and therapeutics in these biologic systems. In 2018, the event focused on contact, kallikrein/kinin, and complement proteins in hereditary angioedema and thrombosis and their developing therapies, as well as kinin receptors in disease, kinin receptor interaction with receptors of the renin-angiotensin system, the influence of the renin angiotensin system with bradykinin and its receptors’ biology, and the influence of this overall system on vascular biology, diabetes, hypertension, heart failure, and other related disease states.
These and related themes were presented in twelve scientific sessions, with four per day, as well as a daily poster session. The meeting’s goals were threefold:
1) to bring together the world’s leading investigators in the field of kinins for the sharing of research and to generate new ideas for future investigation;
2) to emphasize those areas where kinin science is now being translated into clinical use; and
3) to encourage further investigation in this field where progress has been limited.
The manuscripts collected in this volume represent those submitted from authors who gave oral or poster presentations at KININ2018CLE.
Keywords: Factor XII, Kallikrein, Kinin, Renin, Angiotensin
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