Research Topic

Organ Preservation in Treatment of Head and Neck Cancers

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About this Research Topic

Organ preservation with acceptable late functional outcome is becoming the most favourable goal in head and neck cancer treatment since awareness of “coming back to life”-needs of survivors increased. Patient age dropped down especially in ororpharynx cancer in the last years mainly due to HPV. Growing literature regarding rehabilitation, late functional outcome and toxicity is focusing this issue strongly and pushing all in head and neck cancer involved disciplines to stress survival with acceptable late functional outcome and better health related quality of life. Therefore consideration of organ preservation moved from pure anatomical “organ in place” observation to late functional outcome addressing quality of voice, swallowing and social life integration. Moreover the interdisciplinary concepts changed to more personalized compositions and without neglecting the strong evidence of non-surgical multimodality treatment approaches, surgery as a centre discipline in organ preservation is gaining relevance according to rising popularity of transoral access due to new IT and engineering developments. Particularly, new concepts of immune oncology, radiation oncology and promising molecular differentiation are shifting treatment philosophies in a more individualized perspective.
This Research Topic will include topics such as:
New selection criteria for better larynx organ preservation according to the DeLOS-II trial.
Limits and opportunities in open laryngeal organ preservation surgery.
Surgical organ preservation in oropharynx carcinoma.
Deescalation of adjuvant treatment in favour for oropharyngeal organ preservation: lessens from PATHOS.
TORS and beyond in organ preservation surgery.
Perspectives of induction with chemo and/or immune check point inhibition in head and neck organ preservation treatment.
Transoral laser microsurgery (TLM) for organ preservation in larynx/hypopharynx cancer.
Organ preservation and late functional outcome in oropharyngeal carcinoma: rationale of the best of trial.
Monitoring and evaluation of late functional outcome in post treatment follow up in clinical routine setting.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Organ preservation with acceptable late functional outcome is becoming the most favourable goal in head and neck cancer treatment since awareness of “coming back to life”-needs of survivors increased. Patient age dropped down especially in ororpharynx cancer in the last years mainly due to HPV. Growing literature regarding rehabilitation, late functional outcome and toxicity is focusing this issue strongly and pushing all in head and neck cancer involved disciplines to stress survival with acceptable late functional outcome and better health related quality of life. Therefore consideration of organ preservation moved from pure anatomical “organ in place” observation to late functional outcome addressing quality of voice, swallowing and social life integration. Moreover the interdisciplinary concepts changed to more personalized compositions and without neglecting the strong evidence of non-surgical multimodality treatment approaches, surgery as a centre discipline in organ preservation is gaining relevance according to rising popularity of transoral access due to new IT and engineering developments. Particularly, new concepts of immune oncology, radiation oncology and promising molecular differentiation are shifting treatment philosophies in a more individualized perspective.
This Research Topic will include topics such as:
New selection criteria for better larynx organ preservation according to the DeLOS-II trial.
Limits and opportunities in open laryngeal organ preservation surgery.
Surgical organ preservation in oropharynx carcinoma.
Deescalation of adjuvant treatment in favour for oropharyngeal organ preservation: lessens from PATHOS.
TORS and beyond in organ preservation surgery.
Perspectives of induction with chemo and/or immune check point inhibition in head and neck organ preservation treatment.
Transoral laser microsurgery (TLM) for organ preservation in larynx/hypopharynx cancer.
Organ preservation and late functional outcome in oropharyngeal carcinoma: rationale of the best of trial.
Monitoring and evaluation of late functional outcome in post treatment follow up in clinical routine setting.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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