Research Topic

Metabolic Signaling Dysregulation and Cognitive Impairments in Aging and Alzheimer’s Disease

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Aging is the best-known risk factor for Alzheimer's disease (AD), the most common form dementia syndrome and a devastating neurodegenerative disease without any effective therapy available currently. Elucidation of the cellular and molecular mechanisms underlying cognitive decline during normal aging and ...

Aging is the best-known risk factor for Alzheimer's disease (AD), the most common form dementia syndrome and a devastating neurodegenerative disease without any effective therapy available currently. Elucidation of the cellular and molecular mechanisms underlying cognitive decline during normal aging and pathological aging such as AD can provide insights into the identification of novel therapeutic targets and intervention strategies.

Energy metabolism homeostasis is critically important for function and survival of all organisms. The energy demands and metabolic rate of the brain are significant: with less than 2% of the body weight, the brain consumes more than 20% of the body energy. Importantly, dysregulation of energy metabolism in the central nervous system is linked to cognitive impairments in aging and multiple neuronal diseases including AD. While numerous advances have been made in understanding regulation of various molecular signaling cascades in controlling energy metabolism homeostasis, the roles of different metabolic signaling pathways in cognitive impairments and synaptic failure associated with aging and Alzheimer's disease remain unclear.

This Research Topic welcomes contributions, in the form of original research articles or review and opinions, to address/summarize challenges and comprehensions of the roles of various signaling pathways related to metabolic dysregulation in cognitive impairments in aging and Alzheimer's disease-related dementia syndromes (ADRD). Both pre-clinical (basic science) and clinical studies are welcome. Potential topics of interest include but are not limited to the following:

-Oxidative stress and mitochondria function
-Insulin receptor signaling
-Excise and/or diet intervention
-Signaling pathways related to protein synthesis, lipid metabolism
-Signaling pathways involved in glucose metabolism
-Epigenetics regulations
-Pharmacological interventions on metabolic signaling pathways


Keywords: Metabolism, Aging, Alzheimer's, Cognition, Signaling Pathway


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