About this Research Topic
With this Research Topic, we are seeking contributions exploring molecular pathophysiology in autism and the potential therapeutic interventions based on such findings. We will not only focus on the evidence in the above-mentioned cellular events but also on alterations in signaling pathways leading to chaos in neuronal development, local circuitry transmission and circuitry formation in certain brain regions. The scope of this collection of articles is not limited to neurons, glia or microbiome as the interaction or functional modulation among those are also of interest. Studies could be carried out by various approaches such as high throughput screening, biochemistry, electrophysiology, optogenetic, pharmacology. Specific attention will be given to studies that demonstrate the relationship between abnormal signaling and behavioral features of autism. Papers illustrating basic mechanisms in new animal models will also be heavily weighted.
Keywords: Autism, sinaling pathway, neural circuitry, behavior, animal model
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.