About this Research Topic
A number of intracellular signaling pathways are already known to be involved in cancer cell insensitivity to irradiation. Among them are mutations in genes related to DNA damage and repair, activation of intracellular pro-survival signaling pathways, affected cell cycle regulation, compromised cell death machinery, etc. However, microenvironmental factors may also be foreseen to be involved in tumor cell radioresistance. Thus, hypoxia, tumor-associated fibroblasts, immune system cells, micro- and macrophages could also diminish tumor responses to ionizing radiation. Additionally, cancer stem cells (CSC) encapsulate in a single concept many of the above-mentioned explanations of tumor insensitivity to cytotoxic radiotherapy. Therefore, the role of CSCs in tumor formation, development and response to anti-tumor therapies is at present under intense investigation.
In this research topic, we aim to analyze the variety of factors associated with tumor insensitivity to ionizing radiation. We welcome contributions that highlight the following aspects of this subject area:
- Intracellular and intratumoral molecular events associated with radiation resistance;
- Metabolic perturbations in radioresistant carcinoma cells;
- Cancer stem cells (CSC): CSC plasticity, crosstalk with other tumor cells (non-CSCs, fibroblasts, immune system cells, etc.);
- Role of microenvironmental factors In tumor insensitivity to ionizing radiation;
- Molecular biomarkers to predict radiation resistance;
- Molecular targets (including imaging) to improve radiation tumor response;
- Chemical compounds for combination with ionizing radiation;
- Translational research on radiation oncology.
Keywords: Cancer stem cells, Radiation Oncology, resistance, tumor insensitivity, radiation tumor response
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.