Therapeutic Effects of Herbal Medicines: How Can We Best Investigate Bioactive Metabolites?

93.8K

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165

authors

19

articles

Therapeutic Effects of Herbal Medicines: How Can We Best Investigate Bioactive Metabolites?

93.8K

views

165

authors

19

articles

Editorial

29 March 2022

Editorial: Therapeutic Effects of Herbal Medicines: How Can We Best Investigate Bioactive Metabolites?

Shuai Ji

,

Wenzhi Yang

,

Bin Chen

,

Xionghao Lin

, 1 more and

Marcello Locatelli

1,540 views

1 citations

Editors

6

Xuzhou Medical University

Tianjin University of Traditional Chinese Medicine

Affliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine

College of Medicine, Howard University

Peking Union Medical College Hospital (CAMS)

Marcello Locatelli

University of Studies G. d'Annunzio Chieti and Pescara

Impact

About

Herbal medicines contain hundreds or even thousands of primary and secondary metabolites, and it is a vital task for pharmacologists to explore which components contribute to the therapeutic effects of herbal medicines and which compounds do not. The complexity and low content of the chemical constituents of these metabolites in herbal medicines pose complex challenges. Up to now, the active components of most herbal medicines remain obscure, which hinders further pharmacological study and development of herbal medicines.

In general, the absorption of these metabolites needs to be understood in order to evaluate their potential therapeutic effects. Up to now, pharmacologists have tried many methods and techniques to explore the pharmacodynamics of herbal medicines. This includes the in vivo characterization of metabolites by pharmaco-metabonomics techniques or ex vivo models focusing on the delivery, for example, in the gastrointestinal tract.

This Research Topic aims to attract innovative original contributions in the interdisciplinary area in order to understand the relative contribution of different compounds or compound classes to reported pharmacological effects.

We welcome Original Research and Review articles, among other article types, focusing on the following subtopics, but not limited to:
• Profiling of metabolites’ pharmacokinetics in vivo.
• New unreported biological activities.
• New biological targets.
• New bioactive compounds as leads for the pharmaceutical industry.

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All the manuscripts submitted to this project will be peer-reviewed and need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here).

Herbal medicines contain hundreds or even thousands of primary and secondary metabolites, and it is a vital task for pharmacologists to explore which components contribute to the therapeutic effects of herbal medicines and which compounds do not. The complexity and low content of the chemical constituents of these metabolites in herbal medicines pose complex challenges. Up to now, the active components of most herbal medicines remain obscure, which hinders further pharmacological study and development of herbal medicines.

In general, the absorption of these metabolites needs to be understood in order to evaluate their potential therapeutic effects. Up to now, pharmacologists have tried many methods and techniques to explore the pharmacodynamics of herbal medicines. This includes the in vivo characterization of metabolites by pharmaco-metabonomics techniques or ex vivo models focusing on the delivery, for example, in the gastrointestinal tract.

This Research Topic aims to attract innovative original contributions in the interdisciplinary area in order to understand the relative contribution of different compounds or compound classes to reported pharmacological effects.

We welcome Original Research and Review articles, among other article types, focusing on the following subtopics, but not limited to:
• Profiling of metabolites’ pharmacokinetics in vivo.
• New unreported biological activities.
• New biological targets.
• New bioactive compounds as leads for the pharmaceutical industry.

---

All the manuscripts submitted to this project will be peer-reviewed and need to fully comply with the Four Pillars of Best Practice in Ethnopharmacology (you can freely download the full version here).

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Editors

Xuzhou Medical University

Tianjin University of Traditional Chinese Medicine

Affliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine

College of Medicine, Howard University

Peking Union Medical College Hospital (CAMS)

Marcello Locatelli

University of Studies G. d'Annunzio Chieti and Pescara

Impact

93,844 Total views

59,675 Article views

32,787 Article downloads

1,382 Topic views

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Frontiers in Pharmacology

Ethnopharmacology

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