It is the critical importance of the tissue microenvironment (such as hypoxia, low pH, hypertonic microenvironment) for the therapeutic effect, as it would reduce drug delivery, and drug distribution inside some special issues, such as tumor, joint, gum and so on. The nanonization approach can enhance the biochemical, and immunologic properties of drugs, thereby enhancing intracellular tracking, and intelligent response. Extensive studies have shown that nano-drugs with small particle sizes have achieved good results in vitro. However, the nanonization approach has yet to achieve its full potential because it could not overcome unforeseen toxic effects on normal tissues. The nanoparticles’ surface decorated with targeting ligands are well suited for this purpose and have emerged as a promising treatment in recent years. We deemed that utilizing the tumor microenvironment to control drug release is a wise option.
This Research Topic will discuss a few of the many accomplishments of the target-directed drug development programs in nanomedicine. Building on this strategy as one of the most prospective and transformative treatment for improving nanodrugs, we welcome the contribution of original research articles, a review, or perspective articles on the topic of microenvironmental stimuli nanomedicine development for biomedical application. We also welcome the topics that the current status, general trends, challenges, innovative and transformative products or technologies, and future direction in this field.
The aim of this Research Topic is to report recent advancements in smart nanomaterials for biosensing and therapy applications. Both Original Research articles and Review articles are welcome. Preferred subtopics include but are not limited to:
• Functional nanomaterials for cancer therapies
• Smart nanomaterials for treatment of joint disease
• Drug delivery systems for activating osteoblasts to create new bone in tooth
• Therapeutic drug monitoring and/or in vivo imaging
• Rational design of smart nanozyme for biosensing or therapy
• Triggering the immune system with smart nanomaterials
• Mechanistic studies on responses
• New biomaterial synthesis with new stimuli response
• New response release conditions
It is the critical importance of the tissue microenvironment (such as hypoxia, low pH, hypertonic microenvironment) for the therapeutic effect, as it would reduce drug delivery, and drug distribution inside some special issues, such as tumor, joint, gum and so on. The nanonization approach can enhance the biochemical, and immunologic properties of drugs, thereby enhancing intracellular tracking, and intelligent response. Extensive studies have shown that nano-drugs with small particle sizes have achieved good results in vitro. However, the nanonization approach has yet to achieve its full potential because it could not overcome unforeseen toxic effects on normal tissues. The nanoparticles’ surface decorated with targeting ligands are well suited for this purpose and have emerged as a promising treatment in recent years. We deemed that utilizing the tumor microenvironment to control drug release is a wise option.
This Research Topic will discuss a few of the many accomplishments of the target-directed drug development programs in nanomedicine. Building on this strategy as one of the most prospective and transformative treatment for improving nanodrugs, we welcome the contribution of original research articles, a review, or perspective articles on the topic of microenvironmental stimuli nanomedicine development for biomedical application. We also welcome the topics that the current status, general trends, challenges, innovative and transformative products or technologies, and future direction in this field.
The aim of this Research Topic is to report recent advancements in smart nanomaterials for biosensing and therapy applications. Both Original Research articles and Review articles are welcome. Preferred subtopics include but are not limited to:
• Functional nanomaterials for cancer therapies
• Smart nanomaterials for treatment of joint disease
• Drug delivery systems for activating osteoblasts to create new bone in tooth
• Therapeutic drug monitoring and/or in vivo imaging
• Rational design of smart nanozyme for biosensing or therapy
• Triggering the immune system with smart nanomaterials
• Mechanistic studies on responses
• New biomaterial synthesis with new stimuli response
• New response release conditions
