Gastrointestinal tumors are among the top 10 malignant tumors in terms of morbidity and mortality worldwide. Surgical operation is still considered the primary treatment and is usually coupled with comprehensive treatment, including chemotherapy, radiotherapy, targeted therapy and immunotherapy. Despite the significant advances in the treatment landscape of gastrointestinal tumors in recent decades, innovation and development in this field are still expected.
This Research Topic aims to gather Original Research and Review articles focusing on advancing our understanding of the molecular mechanisms of gastrointestinal tumors genesis and development, in the hope to identify new targets and support the development of new drugs that will contribute to clinical treatment.
Subtopics that could be considered for submission include, but are not limited to:
• Cellular and molecular mechanisms underlying tumor oncogenesis and development;
• Tumor interactions with the microenvironment, immune cells, etc.;
• Investigation and validation of the regulatory mechanisms of new molecular targets in tumorigenesis and development of gastrointestinal tumors;
• Use of high-throughput screening and organoid models to validate the mechanisms of actions of new drugs and new potential targets;
• Protein modeling based on existing protein structures or AlphaFold for drug development.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
Gastrointestinal tumors are among the top 10 malignant tumors in terms of morbidity and mortality worldwide. Surgical operation is still considered the primary treatment and is usually coupled with comprehensive treatment, including chemotherapy, radiotherapy, targeted therapy and immunotherapy. Despite the significant advances in the treatment landscape of gastrointestinal tumors in recent decades, innovation and development in this field are still expected.
This Research Topic aims to gather Original Research and Review articles focusing on advancing our understanding of the molecular mechanisms of gastrointestinal tumors genesis and development, in the hope to identify new targets and support the development of new drugs that will contribute to clinical treatment.
Subtopics that could be considered for submission include, but are not limited to:
• Cellular and molecular mechanisms underlying tumor oncogenesis and development;
• Tumor interactions with the microenvironment, immune cells, etc.;
• Investigation and validation of the regulatory mechanisms of new molecular targets in tumorigenesis and development of gastrointestinal tumors;
• Use of high-throughput screening and organoid models to validate the mechanisms of actions of new drugs and new potential targets;
• Protein modeling based on existing protein structures or AlphaFold for drug development.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied.
