Effective treatment of various cancers is still a great challenge for researchers since most drugs in clinical use are associated with adverse side effects, drug resistance, and cancer relapse. There is a global requirement for new research to investigate effective anticancer drugs from synthetic organic, inorganic as well as natural products. Many natural compounds have exhibited their potency to promote apoptosis, inhibit metastasis, and prevent cancer growth. Examples include; Quercetin, Tetrandrine, Curcumin, Silibinin, Thymoquinone, Resveratrol, Honokiol, Diosgenin, Genistein, and Garcinol, among many. Through organic synthesis, complex natural products with therapeutic value can be synthesized economically in sufficient amounts for their clinical use.
On the other hand, many elements are involved in biological systems and the deficiency of such elements can cause a variety of health disorders. In this regard, thousands of metalloenzymes and metalloproteins have been discovered to be part of these biological systems, and supplementation of such elements can cure associated disorders in human and animal health. A few examples of such health disorders include pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient dietary zinc, and heart disease in infants owing to copper deficiency. A wide variety of metal-containing compounds have been explored for their biological activity, and some of them are in clinical use. The ability to recognize, understand at the molecular level, and treat diseases, is an important aspect of medicinal bioinorganic chemistry.
The mission of this Research Topic is to cover recent developments in organic and inorganicanti-cancer compounds, characterization, anti-cancer activities, toxicity and establishment of their mechanism of action. A huge number of bioactive molecules extracted from natural products, as well as their synthetic analogues are under investigation. In the last years few years, advancements made in the biocatalysis and biomaterials fields have contributed to the development of new selective metal-based anticancer agents. Transition metals also have advantages over the more common organic-based drugs, due to their variable coordination numbers, geometries, redox states, structural diversity, and ‘tune-ability’ of the thermodynamics and kinetics of ligand substitution. A large number of metal complexes have been synthesized and tested for their different biological activities, for example; as anticancer agents, anti-inflammatory agents, antibacterial agents, antirheumatic agents, antimalarial agents, and many more. Compounds of metals such as; Silver (Ag), Aluminium (Al), Gold (Au), Arsenic (As), Cobalt (Co), Copper (Cu), Germanium (Ge), Lithium (Li), Molybdenum (Mo), Platinum (Pt), Vanadium (V), and Zinc (Zn) have been approved in clinical use against different diseases. There is an increasing amount of research into metal complexes specifically their synthesis, structure determination, and biological activity. There is a need to explore the biological and medicinal importance of metal complexes.
This Research Topic welcomes submissions on themes including, but not limited to:
• Synthetic organic compounds; characterization and anticancer activity.
• Natural products; characterization and anticancer activity.
• Metal-based compounds; synthesis, characterization, and anticancer activity.
• Anticancer mechanism of drugs
Effective treatment of various cancers is still a great challenge for researchers since most drugs in clinical use are associated with adverse side effects, drug resistance, and cancer relapse. There is a global requirement for new research to investigate effective anticancer drugs from synthetic organic, inorganic as well as natural products. Many natural compounds have exhibited their potency to promote apoptosis, inhibit metastasis, and prevent cancer growth. Examples include; Quercetin, Tetrandrine, Curcumin, Silibinin, Thymoquinone, Resveratrol, Honokiol, Diosgenin, Genistein, and Garcinol, among many. Through organic synthesis, complex natural products with therapeutic value can be synthesized economically in sufficient amounts for their clinical use.
On the other hand, many elements are involved in biological systems and the deficiency of such elements can cause a variety of health disorders. In this regard, thousands of metalloenzymes and metalloproteins have been discovered to be part of these biological systems, and supplementation of such elements can cure associated disorders in human and animal health. A few examples of such health disorders include pernicious anemia resulting from iron deficiency, growth retardation arising from insufficient dietary zinc, and heart disease in infants owing to copper deficiency. A wide variety of metal-containing compounds have been explored for their biological activity, and some of them are in clinical use. The ability to recognize, understand at the molecular level, and treat diseases, is an important aspect of medicinal bioinorganic chemistry.
The mission of this Research Topic is to cover recent developments in organic and inorganicanti-cancer compounds, characterization, anti-cancer activities, toxicity and establishment of their mechanism of action. A huge number of bioactive molecules extracted from natural products, as well as their synthetic analogues are under investigation. In the last years few years, advancements made in the biocatalysis and biomaterials fields have contributed to the development of new selective metal-based anticancer agents. Transition metals also have advantages over the more common organic-based drugs, due to their variable coordination numbers, geometries, redox states, structural diversity, and ‘tune-ability’ of the thermodynamics and kinetics of ligand substitution. A large number of metal complexes have been synthesized and tested for their different biological activities, for example; as anticancer agents, anti-inflammatory agents, antibacterial agents, antirheumatic agents, antimalarial agents, and many more. Compounds of metals such as; Silver (Ag), Aluminium (Al), Gold (Au), Arsenic (As), Cobalt (Co), Copper (Cu), Germanium (Ge), Lithium (Li), Molybdenum (Mo), Platinum (Pt), Vanadium (V), and Zinc (Zn) have been approved in clinical use against different diseases. There is an increasing amount of research into metal complexes specifically their synthesis, structure determination, and biological activity. There is a need to explore the biological and medicinal importance of metal complexes.
This Research Topic welcomes submissions on themes including, but not limited to:
• Synthetic organic compounds; characterization and anticancer activity.
• Natural products; characterization and anticancer activity.
• Metal-based compounds; synthesis, characterization, and anticancer activity.
• Anticancer mechanism of drugs
