Research Topic

Post-genomic mechanistic and applied insights on Aspergillus fumigatus host-pathogen interactions

  • Submission closed.

About this Research Topic

Diseases caused by Aspergillus fumigatus, the most prevalent of human mould pathogens, afflict humans having diverse immunological defects and are associated with high morbidity and mortality. From an ecological view point this organism is important for recycling of organic matter and its ...

Diseases caused by Aspergillus fumigatus, the most prevalent of human mould pathogens, afflict humans having diverse immunological defects and are associated with high morbidity and mortality. From an ecological view point this organism is important for recycling of organic matter and its ubiquitouspresence in the natural environment ensures, via inhalation of airborne spores, a frequent interaction with the human pulmonary system. This host-pathogen interaction often results in damage to the host, the nature of which can be highly variable and is strictly dependent upon host immune status. In the post-genomic era our understanding of the A. fumigatus host-pathogen interaction has expanded dramatically and promises to empower the quest for novel therapeutic interventions and diagnostics. This research topic addresses both host- and pathogen-associated drivers of disease, including: The composition and regulatory control of fungal cell membrane and cell wall; host-adaptation; biosynthesis and secretion of proteases and small molecules implicated in virulence; role of innate immune cells in the host response; host-derived biomarkers of infection and the relevance of microbial interactions to disease progression.


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top