Research Topic

Electrochemical Sensors and Biosensors in Medical and Pharmaceutical Bioanalysis

About this Research Topic

As a general definition, bioanalysis represents the application of analytical techniques in medical and biological sciences. Bioanalysis is a sub-discipline of analytical chemistry covering the quantitative measurement of a compound or metabolite in biological fluids. A bioanalytical method consists of two main components, sample preparation and detection of the compound. The development of novel and improved analytical tools for rapid, selective and sensitive detection is a wide and dynamic field of research. From the array of devices and techniques used for bioanalysis, electrochemical sensors and biosensors have been extensively studied and are now readily available on the market as products for human health monitoring. For example, the glucose biosensor is sold in large quantities and detects blood glucose levels. Glucose meters are universally available and provide fast analysis of blood glucose levels to enable effective management of both hypoglycemic and hyperglycemic disorders.

Recent advancements in the field of electrochemical sensors and biosensors for bioanalysis have improved the detection of biomolecules, drug and drug metabolites for human health monitoring. The availability of nanomaterials and biological receptors has enabled the fabrication of sophisticated bionanocomposite materials. Medical and pharmaceutical samples often have multiple components that require detection which necessitates the development of sensitive multifaceted biosensors. This can be achieved by using precise techniques for the deposition of each component as thin layers, the control of the molecular architecture and the preservation of the sensitive properties in a biomimetic environment. All these features could facilitate the development of sensitive devices with improved detection properties in multicomponent samples, as are medical or pharmaceutical samples.

Electrochemical sensors are designed by coupling the receptor part of the device to an electrochemical transducer. The transducer transforms the analytical information originating from the electrochemical interaction (analyte-electrode) into a measurable electrical signal. The versatility of electrochemical measurement systems is a significant advantage of these analytical tools, which can be easily implemented in practice because they are small, portable, low-power, do not require specialized users, need few chemicals, and can be used in real time analysis. All these advantages make the development of complementary methods of analysis useful in the diagnosis or in monitoring of health status as screening methods.

This Research Topic welcomes the contribution of original research papers and reviews covering current research in the characterization and development of electrochemical sensors and biosensors for medical and pharmaceutical bioanalysis. The aim of the Research Topic is to present the most recent scientific developments in bioanalysis based on electrochemical sensors and biosensors. Potential topics can include but are not limited to:
• Characterization of electrochemical sensors and biosensors by physical, chemical, microscopic and electrochemical techniques.
• Design of electrochemical sensors and biosensors that detect multicomponent medical and pharmaceutical samples.
• Development of analytical methods for the quantification of analyst useful in bioanalysis.
• Validation of electrochemical sensors and biosensors during pharmaceutical or medical analysis.


Keywords: ​B​iosensor, ​S​ensor, ​E​lectrochemistry, ​B​ioanalysis, ​V​alidation, Bionanocomposite


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

As a general definition, bioanalysis represents the application of analytical techniques in medical and biological sciences. Bioanalysis is a sub-discipline of analytical chemistry covering the quantitative measurement of a compound or metabolite in biological fluids. A bioanalytical method consists of two main components, sample preparation and detection of the compound. The development of novel and improved analytical tools for rapid, selective and sensitive detection is a wide and dynamic field of research. From the array of devices and techniques used for bioanalysis, electrochemical sensors and biosensors have been extensively studied and are now readily available on the market as products for human health monitoring. For example, the glucose biosensor is sold in large quantities and detects blood glucose levels. Glucose meters are universally available and provide fast analysis of blood glucose levels to enable effective management of both hypoglycemic and hyperglycemic disorders.

Recent advancements in the field of electrochemical sensors and biosensors for bioanalysis have improved the detection of biomolecules, drug and drug metabolites for human health monitoring. The availability of nanomaterials and biological receptors has enabled the fabrication of sophisticated bionanocomposite materials. Medical and pharmaceutical samples often have multiple components that require detection which necessitates the development of sensitive multifaceted biosensors. This can be achieved by using precise techniques for the deposition of each component as thin layers, the control of the molecular architecture and the preservation of the sensitive properties in a biomimetic environment. All these features could facilitate the development of sensitive devices with improved detection properties in multicomponent samples, as are medical or pharmaceutical samples.

Electrochemical sensors are designed by coupling the receptor part of the device to an electrochemical transducer. The transducer transforms the analytical information originating from the electrochemical interaction (analyte-electrode) into a measurable electrical signal. The versatility of electrochemical measurement systems is a significant advantage of these analytical tools, which can be easily implemented in practice because they are small, portable, low-power, do not require specialized users, need few chemicals, and can be used in real time analysis. All these advantages make the development of complementary methods of analysis useful in the diagnosis or in monitoring of health status as screening methods.

This Research Topic welcomes the contribution of original research papers and reviews covering current research in the characterization and development of electrochemical sensors and biosensors for medical and pharmaceutical bioanalysis. The aim of the Research Topic is to present the most recent scientific developments in bioanalysis based on electrochemical sensors and biosensors. Potential topics can include but are not limited to:
• Characterization of electrochemical sensors and biosensors by physical, chemical, microscopic and electrochemical techniques.
• Design of electrochemical sensors and biosensors that detect multicomponent medical and pharmaceutical samples.
• Development of analytical methods for the quantification of analyst useful in bioanalysis.
• Validation of electrochemical sensors and biosensors during pharmaceutical or medical analysis.


Keywords: ​B​iosensor, ​S​ensor, ​E​lectrochemistry, ​B​ioanalysis, ​V​alidation, Bionanocomposite


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

27 October 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

27 October 2019 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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