About this Research Topic
Gaps exist in our understanding of the molecular interactions within CSCs, their maintenance in niches, their ability to divide unequally that commits to both self-renewal and tumor heterogeneity, and their capacity to confer chemoresistance. In addition, defining the natural roles of stem cells and stem cell genes during early stages of tissue development may help in understanding the functional involvement of CSCs and CSC genes in cancer in relation to cell propagation and specific cell lineages.
Desired contributions
This topic covers the area of the molecular biology of CSCs where modern methodologies, recent findings, and critical reviews shed light into the multiple roles of CSCs and provide a platform to define relevant translational and targeting therapeutic options. Researchers involved in these areas of CSC studies are particularly encouraged to submit their manuscripts to this topic.
Keywords: Cancer stem cells, stem cells, genetics, biomarkers, therapeutics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.