The vascular endothelium is not a static barrier, but rather a barrier that dynamically interacts with itself, with its environment and with other cell types. As such, endothelial cells are equipped with a variety of molecular systems that control dynamic rearrangements during inflammation, immune surveillance, and angiogenesis. Studying the systems that underlie endothelial dynamics brings fundamental insights into how blood vessels form and respond to changes in their microenvironment. This knowledge will be crucial to understand the development of diseases that involve vascular remodeling, and it provides potential leads to steer the opening and closing of the vasculature for therapeutic applications in inflammatory disease, blood-brain barrier and cancer metastasis.
The objective to launch this Research Topic is to bring together current views on how dynamic molecular systems relate to endothelial responses within blood vessels. We aim to highlight molecular events that take place at the level of (1) individual endothelial cells, (2) endothelial cell collectives, (3) the interface between endothelial and circulating immune and/or cancer cells, (4) the embedding of the endothelium within the vessel wall and (5) blood flow sensing by the endothelium. Given the recognized power of fluorescence microscopy in this field, we especially welcome novel ideas, models and methods involving imaging to challenge current dogma’s in the field.
Topics include:
1. Mechanotransduction
2. Intracellular and angiocrine signaling
3. Cell adhesion
4. In vitro models for endothelial dynamics
5. In vivo models for endothelial dynamics
In this research topic we encourage submission of reviews, mini-reviews, original research papers and methods papers covering various dynamic processes of endothelial biology up to their implication for vascular disease and therapeutics.
The vascular endothelium is not a static barrier, but rather a barrier that dynamically interacts with itself, with its environment and with other cell types. As such, endothelial cells are equipped with a variety of molecular systems that control dynamic rearrangements during inflammation, immune surveillance, and angiogenesis. Studying the systems that underlie endothelial dynamics brings fundamental insights into how blood vessels form and respond to changes in their microenvironment. This knowledge will be crucial to understand the development of diseases that involve vascular remodeling, and it provides potential leads to steer the opening and closing of the vasculature for therapeutic applications in inflammatory disease, blood-brain barrier and cancer metastasis.
The objective to launch this Research Topic is to bring together current views on how dynamic molecular systems relate to endothelial responses within blood vessels. We aim to highlight molecular events that take place at the level of (1) individual endothelial cells, (2) endothelial cell collectives, (3) the interface between endothelial and circulating immune and/or cancer cells, (4) the embedding of the endothelium within the vessel wall and (5) blood flow sensing by the endothelium. Given the recognized power of fluorescence microscopy in this field, we especially welcome novel ideas, models and methods involving imaging to challenge current dogma’s in the field.
Topics include:
1. Mechanotransduction
2. Intracellular and angiocrine signaling
3. Cell adhesion
4. In vitro models for endothelial dynamics
5. In vivo models for endothelial dynamics
In this research topic we encourage submission of reviews, mini-reviews, original research papers and methods papers covering various dynamic processes of endothelial biology up to their implication for vascular disease and therapeutics.
