About this Research Topic
Currently, mesenchymal stem/stromal cells (MSCs) are among the most used cells in clinical trials. Whereas many characteristics of these cells have been described to date, aspects of their basic biology that may have an impact on their use in regenerative medicine are still under investigation. Likewise, in spite of the successful use of these cells in tissue engineering and cell therapy scenarios, further work on ways to enhance their aptitude for therapeutic purposes are still under development.
The aim of this Research Topic is to provide a venue for high quality research articles and reviews that broaden the knowledge on the biology of mesenchymal stem/stromal cells, including mechanisms that can affect their role as agents in cell therapy and tissue engineering. Manuscripts submitted to this Research Topic are expected to contain information that can be used to better understand how MSCs behave, and how they exert their therapeutic properties, whether such information comes from in vitro or in vivo studies.
Potential topics include but are not limited to the following:
Novel features of MSCs from different tissues
Molecular aspects of MSC differentiation
Processes for the enhancement of MSC differentiation and expansion in culture
Identification of MSCs, or cells that can give rise to them, in situ
Acellular MSC-derived products (e.g., extracellular vesicles)
Immunomodulatory properties of MSCs
Molecular interactions between MSCs with other cell types in vitro or in vivo
Keywords: Mesenchymal Stem Cell, Differentiation, Immunomodulatory Products, Intercellular Interactions, Regenerative Medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.