About this Research Topic
Over the past decades, mesenchymal stem cell (MSC)-based therapy has attracted worldwide attention and shown promising results for a variety of traumatic and degenerative disorders in animal studies and clinical trials due to their several advantages, including easy isolation and expansion, multi-lineage differentiation, and low immunogenicity. Nevertheless, MSCs derived from elder populations or following prolonged culture expansion in vitro become senescent. The senescent MSCs exhibit decreased self-renewal and differentiation capacity. Moreover, senescent MSCs secrete a wide spectrum of factors, termed “senescence-associated secretory phenotype (SASP)”, which has deleterious effects on their therapeutic potential. Therefore, rejuvenating the senescent MSCs to enhance their therapeutic potential is of great significance.
Indeed, MSC senescence has been intensively investigated. Several potential mechanisms including reactive oxygen species (ROS), telomere shortening and autophagy, are involved in MSC senescence; however, the precise molecular network still remains unclear. Thus, a better understanding of the molecular mechanisms underlying MSC senescence could contribute to develop novel strategies to rejuvenate the senescent MSCs. A growing body of evidence demonstrates that rejuvenating the senescent MSCs can enhance the therapeutic efficacy for several disorders such as myocardial infarction and age-related bone loss. Currently, several interventions including hypoxia, pharmacological approaches and genetic modification have been explored to rejuvenate the senescent MSCs. However, many challenges need to be overcome.
In this Research Topic, we are welcoming original research and review articles on the potential mechanisms underlying MSC senescence. Moreover, the goal is to identify MSC senescent biomarkers and develop innovative strategies to rejuvenate the senescent MSCs to enhance their therapeutic efficacy. The following topics may be included, but are not limited to:
• Molecular players (e.g. miRNA, ROS)underpinning MSC senescence
• Biomarkers for MSC senescence
• Mechanisms of autophagy and MSC senescence
• Novel methods to monitor MSC senescence
• Exploring novel strategies to rejuvenate MSC senescence and their therapeutic efficacy for several diseases
Keywords: Mesenchymal Stem Cell, Senescence, Rejuvenation, Therapeutic Efficacy
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