About this Research Topic
Rapid technological advances in mechanical circulatory support devices over the last two decades have been staggering. These devices improve systemic circulation and save critically ill patients with acute and chronic diseases. The development of percutaneous mechanical support devices has allowed for rapid and less invasive insertion of these lifesaving machines. Surgical devices are larger, offer higher flow rates, and are durable, thus allowing long-term management of patients. Recent data indicate that the benefit of these devices is not limited to improved circulatory support, but that the physiological and molecular effects of cardiac unloading confer separate beneficial effects on the heart and improve patient outcomes. To take maximum advantage of these emerging clinical tools, it is essential that we understand the device-specific and disease-dependent impacts of these various devices on hemodynamics, the heart, and other organs.
In this research topic, we aim to collect manuscripts that focus on understanding the impact of mechanical cardiac and circulatory assist devices in both acute and chronic settings. We are also interested in the innovative use and application of these devices. Below are examples of areas with our high interest.
• Impact of acute/chronic cardiac unloading
• Cardiac physiology under mechanical
• Acute cardiac unloading in cardiogenic
• Hemodynamic monitoring and prediction
(modeling) under mechanical circulatory
• Mechanical cardiac support and kidney
• New devices and new application of existing
cardiac support devices
• Optimizing patient selection for mechanical
Our goal is to improve application and care of mechanical circulatory support through combined scientific knowledge in molecular, physiological, clinical and device aspects. Original Research papers, Reviews and Methodology manuscripts are welcome. All basic, translational, and clinical studies are within the scope of this topic.
Keywords: LVAD, Mechanical Unloading, LV Unloading, Physiology, Heart Failure
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.