Research Topic

Genetic, Epigenetic, and Epitranscriptomic Mechanisms Associated with Learning and Memory

About this Research Topic

Learning and memory are key brain functions required for the acquisition, storage and retrieval of novel knowledge. To date, large collections of genes have been associated with learning and memory processes. Specifically, recent studies on neuronal activation, driven by learning and memory paradigms, have revealed that both epigenetic modifications on these genes and epitranscriptomic modifications on their messenger RNAs are essential for the assembly and maintenance of neural circuits. However, such molecular mechanisms remain largely unexplored and little is known of the epigenetic and epitranscriptomic control/maintenance/regulation of our thoughts, feelings and behaviours.

This Research Topic is particularly interested in the understanding of genetic, epigenetic, and epitranscriptomic regulatory mechanisms of neuronal plasticity. Upon neuronal activation, external stimuli initiate signal transduction cascades to regulate gene expression via epigenetic/epitranscriptomic modifications. Molecular aberrations in these regulatory pathways contribute to various kinds of learning disability and memory deficits. The identification of genetic mutations and epigenetic abnormalities in writers, erasers and readers of epigenetic/epitranscriptomic marks will improve our understanding of neurological diseases and complications, including autism, schizophrenia, addiction, and Alzheimer’s diseases. We appreciate studies using combinatory technologies including genetic/epigenetic manipulation, cellular and molecular analyses of neuronal systems and behavioural test batteries.


Keywords: Epigenetic, DNA methylation, histone modification, behavior, learning and memory


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Learning and memory are key brain functions required for the acquisition, storage and retrieval of novel knowledge. To date, large collections of genes have been associated with learning and memory processes. Specifically, recent studies on neuronal activation, driven by learning and memory paradigms, have revealed that both epigenetic modifications on these genes and epitranscriptomic modifications on their messenger RNAs are essential for the assembly and maintenance of neural circuits. However, such molecular mechanisms remain largely unexplored and little is known of the epigenetic and epitranscriptomic control/maintenance/regulation of our thoughts, feelings and behaviours.

This Research Topic is particularly interested in the understanding of genetic, epigenetic, and epitranscriptomic regulatory mechanisms of neuronal plasticity. Upon neuronal activation, external stimuli initiate signal transduction cascades to regulate gene expression via epigenetic/epitranscriptomic modifications. Molecular aberrations in these regulatory pathways contribute to various kinds of learning disability and memory deficits. The identification of genetic mutations and epigenetic abnormalities in writers, erasers and readers of epigenetic/epitranscriptomic marks will improve our understanding of neurological diseases and complications, including autism, schizophrenia, addiction, and Alzheimer’s diseases. We appreciate studies using combinatory technologies including genetic/epigenetic manipulation, cellular and molecular analyses of neuronal systems and behavioural test batteries.


Keywords: Epigenetic, DNA methylation, histone modification, behavior, learning and memory


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

31 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

31 October 2020 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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