About this Research Topic
Organoids are an emerging research tool in stem cell biology, regenerative medicine, virology and cancer biology. These highly physiologically relevant organoid models appear as an ideal system to recapitulate many of the central aspects of tumor microenvironment including 3D morphology and polarized expression of differentiation and stem cell markers. Many such markers are lost in established cell lines. Furthermore, tumor organoids could be genetically engineered using virus-meditated gene delivery or generated from genetically modified animals. Importantly, a subset of the patient-derived organoids can be grown in minimally supplemented serum-free media, which is desirable for some experimental interrogations such as nutrient supplementation.
To make full utilization of organoids, optimized culture conditions, assay reagents as well as novel culture protocols are key. Genetically engineered organoids have perfectly modeled cancer initiation and progression, which has shortened the time and cost of mechanistic investigation. Construction of organoids biobank has helped to gain new insights in developing personalized treatment regimens for patients. In this context, the aim of this Research Topic is to gather promising, recent, and novel research trends in the organoids towards cancer biology field.
Areas to be covered in this Research Topic may include, but are not limited to:
• Optimization of culture conditions.
• Development of novel culture protocols (eg. co-culture with immune cells).
• Use of organoids for disease diagnosis.
• Application of the organoids in the mechanistic studies of cancer development.
• Use of organoids as model systems for personalized medicine.
We welcome Original Research, Methods and Review articles.
Keywords: Organoids, Cancer Biology, Organoids Biobank, Tumor Organoids
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.