About this Research Topic
The different aspects of cancer metabolic rewiring were addressed at the 6th annual meeting of the International Society of Cancer Metabolism (ISCaM) in Braga, Portugal, on October 17-19, 2019. In this meeting, a comprehensive program was set that tackled the many faces of cancer metabolism, highlighting the recent advances in the field and the road ahead for clinical translation. The meeting sessions focused on more traditional topics such as the understanding and targeting of cancer pH dynamics, genetic and epigenetic regulation of cancer metabolism, tumor metabolic heterogeneity, contribution of metabolic alterations to cancer progression, induction of programmed cell death, to current hot topics, namely the role of diet and microbiota in cancer metabolism, metabolic reprogramming and immune response, and cancer metabolism as a challenging target for therapy.
This article collection will highlight the topics discussed during the meeting sessions in a series of mini-review articles:
1) Intracellular pH dynamics and cancer cell behaviors
2) Metformin: A multi-faceted modulator of the epigenetic landscape
3) Metabolic aspects of palladium (II) potential anti-cancer drugs
4) Cysteine and glutathione, challenging cancer cells to death
5) Cysteine metabolism, a hot spot in cancer cell survival
6) Dysregulation of autophagy by inflammatory cytokines and its impact on cancer progression
7) The interplay between immune cell metabolism and function
8) Microbiota manipulation by diet and probiotics as an emerging tool in cancer therapy and management
Keywords: cancer metabolism
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