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This section of the journal will focus on the basic science, translational and clinical aspects of Cancer Metabolism, with a particular emphasis on energy metabolism and metabolic reprogramming in cancer cells. This broadly includes mitochondrial, glycolytic, fatty acid, as well as other forms of metabolism. We are also interested in how driver mutations, gene expression and epigenetic regulation influence metabolism in cancer cells.
Novel research will be considered for this section which is pertaining to metabolic reprogramming, metabolic flexibility, altered pathways of metabolism, tumor initiation, progression and metastasis, EMA/FDA-approved drug repurposing, development of new pharmacological therapies, as well as metabolic changes affecting the tumor microenvironment. Of particular interest is research on induction of metabolic inflexibility in cancer cells, and methods of targeting such cells for effective treatment.
We aim to provide a supportive and constructive framework to facilitate the development and implementation of new metabolic therapies, with the goal of preventing treatment failure (recurrence and metastasis), which is largely due to metabolic flexibility or plasticity in cancer cells, while minimizing the side-effects of cancer therapy. This section welcomes clinical aspects of research, as well as basic and translational studies in the subject.
Indexed in: PubMed, PubMed Central, Scopus, Google Scholar, DOAJ, CrossRef, Chemical Abstracts Service (CAS), Science Citation Index Expanded, CLOCKSS
PMCID: all published articles receive a PMCID
Cancer Metabolism welcomes submissions of the following article types: Case Report, Classification, Clinical Trial, Correction, Data Report, Editorial, General Commentary, Hypothesis and Theory, Mini Review, Original Research, Perspective, Review, Specialty Grand Challenge and Systematic Review.
All manuscripts must be submitted directly to the section Cancer Metabolism, where they are peer-reviewed by the Associate and Review Editors of the specialty section.
Articles published in the section Cancer Metabolism will benefit from the Frontiers impact and tiering system after online publication. Authors of published original research with the highest impact, as judged democratically by the readers, will be invited by the Chief Editor to write a Frontiers Focused Review - a tier-climbing article. This is referred to as "democratic tiering". The author selection is based on article impact analytics of original research published in all Frontiers specialty journals and sections. Focused Reviews are centered on the original discovery, place it into a broader context, and aim to address the wider community across all of Oncology.
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